Abstract
Mycobacterium leprae was isolated and purified from lepromas, the spleen, and the liver of leprosy patients. An immunodiffusion analysis of the cytoplasms obtained from four lots of M. leprae and M. lepraemurium, 295 strains of different actinomycetales, and 12 other bacteria was performed with the use of the cytoplasm antisera. Immunological relationships were revealed between the cytoplasms of M. leprae, M. lepraemurium, M. avium, M. gallinarum, M. tuberculosis, M. simiae, M. kansasii, M. chitae, M. capsulatum, Actinomyces israelii, A. naeslundii, and some strains of saprophytic mycobacteria. These studies led to the proposed concept of the immunological evolution of M. leprae and M. lepraemurium and an Actinomyces-like progenitor through M. avium—M. gallinarum and to a proposal for the polyvalent vaccine currently being developed by this research group.
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Selected References
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- Kwapinski J. B., Alcasid A. Immunological characterization of cytoplasm antigens of non-photochromogenic mycobacteria. Can J Microbiol. 1972 Apr;18(4):445–448. doi: 10.1139/m72-069. [DOI] [PubMed] [Google Scholar]
- Kwapinski J. B., Alcasid A. Serological relationships between cytoplasms of scotochromogenic mycobacteria. Can J Microbiol. 1970 Dec;16(12):1263–1266. doi: 10.1139/m70-211. [DOI] [PubMed] [Google Scholar]
- Kwapinski J. B. Serological characteristics of particulate antigens of Dermatophilus. Can J Microbiol. 1969 Oct;15(10):1141–1144. doi: 10.1139/m69-208. [DOI] [PubMed] [Google Scholar]