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. 1972;47(1):113–122.

Research needs in leptospirosis*

PMCID: PMC2480810  PMID: 4563541

Abstract

Leptospirosis is a widespread infection of man and animals, and locally it assumes considerable importance as a public health and economic problem. It is an important occupational infection among persons working with animals or in environments that may be contaminated by infected animals. In recent years, considerable attention has been devoted to this infection but efforts to control and eliminate it, especially from natural foci, are hindered by gaps in our knowledge. This memorandum is a review of recent progress and current problems in leptospirosis research, with special reference to taxonomy, epidemiological methods, and control measures. Certain aspects of the basic biology of leptospires that are relevant to these topics are also discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson D. L., Johnson R. C. Electron microscopy of immune disruption of leptospires: action of complement and lysozyme. J Bacteriol. 1968 Jun;95(6):2293–2309. doi: 10.1128/jb.95.6.2293-2309.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baseman J. B., Cox C. D. Intermediate energy metabolism of Leptospira. J Bacteriol. 1969 Mar;97(3):992–1000. doi: 10.1128/jb.97.3.992-1000.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baseman J. B., Cox C. D. Terminal electron transport in Leptospira. J Bacteriol. 1969 Mar;97(3):1001–1004. doi: 10.1128/jb.97.3.1001-1004.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bazovská S., Kmety E. Príspevok k otázke transformácie leptospír. Bratisl Lek Listy. 1967 Feb 28;47(4):205–208. [PubMed] [Google Scholar]
  5. Borg-Petersen C. A thermo-labile antigen in the Leptospira strain Ictero No. I. Trop Geogr Med. 1971 Sep;23(3):282–285. [PubMed] [Google Scholar]
  6. Chang A., Faine S. Electron-microscopic evidence for reactions of axial filaments of Leptospira with IgM and IgG antibodies. Bull World Health Organ. 1970;43(4):571–577. [PMC free article] [PubMed] [Google Scholar]
  7. ELLINGHAUSEN H. C., Jr, MCCULLOUGH W. G. NUTRITION OF LEPTOSPIRA POMONA AND GROWTH OF 13 OTHER SEROTYPES: A SERUM-FREE MEDIUM EMPLOYING OLEIC ALBUMIN COMPLEX. Am J Vet Res. 1965 Jan;26:39–44. [PubMed] [Google Scholar]
  8. FAINE S., VANDERHOEDEN J. VIRULENCE-LINKED COLONIAL AND MORPHOLOGICAL VARIATION IN LEPTOSPIRA. J Bacteriol. 1964 Nov;88:1493–1496. doi: 10.1128/jb.88.5.1493-1496.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Green S. S., Goldberg H. S., Blenden D. C. Enzyme patterns in the study of leptospira. Appl Microbiol. 1967 Sep;15(5):1104–1113. doi: 10.1128/am.15.5.1104-1113.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Haapala D. K., Rogul M., Evans L. B., Alexander A. D. Deoxyribonucleic acid base composition and homology studies of Leptospira. J Bacteriol. 1969 May;98(2):421–428. doi: 10.1128/jb.98.2.421-428.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Johnson R. C., Harris V. G. Antileptospiral activity of serum. II. Leptospiral virulence factor. J Bacteriol. 1967 Feb;93(2):513–519. doi: 10.1128/jb.93.2.513-519.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Johnson R. C., Harris V. G. Purine analogue sensitivity and lipase activity of leptospires. Appl Microbiol. 1968 Oct;16(10):1584–1590. doi: 10.1128/am.16.10.1584-1590.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Johnson R. C., Harris V. G., Walby J. K. Characterization of leptospires according to fatty acid requirements. J Gen Microbiol. 1969 Mar;55(3):399–407. doi: 10.1099/00221287-55-3-399. [DOI] [PubMed] [Google Scholar]
  14. Johnson R. C., Livermore B. P., Walby J. K., Jenkin H. M. Lipids of parasitic and saprophytic leptospires. Infect Immun. 1970 Sep;2(3):286–291. doi: 10.1128/iai.2.3.286-291.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. KEMENES F. (CROSS-IMMUNITY STUDIES ON VIRULENT STRAINS OF LEPTOSPIRES BELONGING TO DIFFERENT SEROTYPES.) Z Immunitats Allergieforsch. 1964 Aug;127:209–229. [PubMed] [Google Scholar]
  16. Kasarov L. B., Addamiano L. Metabolism of the lipoproteins of serum by leptospires: degradation of the triglycerides. J Med Microbiol. 1969 May;2(2):165–168. doi: 10.1099/00222615-2-2-165. [DOI] [PubMed] [Google Scholar]
  17. Kasărov L. B. Degradiation of the erythrocyte phospholipids and haemolysis of the erythrocytes of different animal species by leptospirae. J Med Microbiol. 1970 Feb;3(1):29–37. doi: 10.1099/00222615-3-1-29. [DOI] [PubMed] [Google Scholar]
  18. Kmety E. Comparative studies of some recently described new leptospiral serotypes. Trop Geogr Med. 1970 Sep;22(3):357–363. [PubMed] [Google Scholar]
  19. Livermore B. P., Johnson R. C., Jenkin H. M. Isolation of an unusual positional isomer of hexadecenoic acid from a parasitic leptospire. Lipids. 1969 Mar;4(2):166–167. doi: 10.1007/BF02531939. [DOI] [PubMed] [Google Scholar]
  20. Nauman R. K., Holt S. C., Cox C. D. Purification, ultrastructure, and composition of axial filaments from Leptospira. J Bacteriol. 1969 Apr;98(1):264–280. doi: 10.1128/jb.98.1.264-280.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Pillot J., Ryter A. Structure des spirochètes. 1. Etude des generes Treponema, Borrelia et Leptospira au microscope electronique. Ann Inst Pasteur (Paris) 1965 Jun;108(6):791–804. [PubMed] [Google Scholar]
  22. Plesko I., Lataste-Dorolle C. Immunité croisée en leptospirose expérimentale. Effets protecteurs réciproques réalisés par des souches Grippotyphosa et des souches d'autres sérogroupes. Ann Inst Pasteur (Paris) 1970 Oct;119(4):456–467. [PubMed] [Google Scholar]
  23. RITCHIE A. E., ELLINGHAUSEN H. C. ELECTRON MICROSCOPY OF LEPTOSPIRES. I. ANATOMICAL FEATURES OF LEPTOSPIRA POMONA. J Bacteriol. 1965 Jan;89:223–233. doi: 10.1128/jb.89.1.223-233.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Shenberg E. Growth of pathogenic Leptospira in chemically defined media. J Bacteriol. 1967 May;93(5):1598–1606. doi: 10.1128/jb.93.5.1598-1606.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Stalheim O. H. Leptospiral selection, growth, and virulence in synthetic medium. J Bacteriol. 1966 Oct;92(4):946–951. doi: 10.1128/jb.92.4.946-951.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Stalheim O. H. Vaccination of hamsters, swine, and cattle with viable, avirulent Leptospira pomona. Am J Vet Res. 1968 Jul;29(7):1463–1468. [PubMed] [Google Scholar]
  27. Stern N., Shenberg E., Tietz A. Studies on the metabolism of fatty acids in Leptospira: the biosynthesis of delta 9- and delta 11-monounsaturated acids. Eur J Biochem. 1969 Mar;8(1):101–108. doi: 10.1111/j.1432-1033.1969.tb00501.x. [DOI] [PubMed] [Google Scholar]
  28. Turner L. H. Leptospirosis. 3. Maintenance, isolation and demonstration of leptospires. Trans R Soc Trop Med Hyg. 1970;64(4):623–646. doi: 10.1016/0035-9203(70)90087-8. [DOI] [PubMed] [Google Scholar]
  29. Yanagawa R., Faine S. Morphological and serological analysis of leptospiral structure. Nature. 1966 Aug 20;211(5051):823–826. doi: 10.1038/211823a0. [DOI] [PubMed] [Google Scholar]
  30. Yanagihara Y., Mifuchi I. Microfibers present in surface structure of Leptospira. J Bacteriol. 1968 Jun;95(6):2403–2406. doi: 10.1128/jb.95.6.2403-2406.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]

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