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. 1972;47(5):549–557.

A clinical and pathological study of schistosomal nephritis*

M S Sabbour, W El-Said, I Abou-Gabal
PMCID: PMC2480839  PMID: 4540673

Abstract

In a Cairo clinic 17 of 41 patients with chronic pyelonephritis secondary to urinary schistosomiasis presented with classical features of the nephrotic syndrome, two-thirds being hypertensive and the majority having glomerular filtration rates within the normal range. Hypercholesterolaemia was found in one-third of the patients. Urinary sediments from these patients contained a preponderance of pus cells, red cells, granular casts, or pus casts. In addition to patches of pyelonephritis, the glomeruli showed diffuse and focal glomerulosclerosis. Electron microscopy revealed basement-membrane-like deposits in the hypertrophied axial endothelial cells and electron-dense deposits along the glomerular basement membrane. This variety of nephrotic syndrome associated with schistosomal pyelonephritis was the most common cause of nephrotic syndrome seen in the clinic.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrade Z. A., Andrade S. G., Sadigursky M. Renal changes in patients with hepatosplenic schistosomiasis. Am J Trop Med Hyg. 1971 Jan;20(1):77–83. doi: 10.4269/ajtmh.1971.20.77. [DOI] [PubMed] [Google Scholar]
  2. Andrade Z. A., Paronetto F., Popper H. Immunocytochemical Studies in Schistosomiasis. Am J Pathol. 1961 Nov;39(5):589–598. [PMC free article] [PubMed] [Google Scholar]
  3. Andrade Z. A., de Queiroz A. C. Lesões renais na esquistossomose hepatesplênica. Rev Inst Med Trop Sao Paulo. 1968 Jan-Feb;10(1):36–40. [PubMed] [Google Scholar]
  4. Cameron J. S. Nephrotic syndrome. Br Med J. 1970 Nov 7;4(5731):350–353. doi: 10.1136/bmj.4.5731.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fisher E. R., Perez-Stable E. Cirrhotic (hepatic) lobular glomerulonephritis. Correlation of ultrastructural and clinical features. Am J Pathol. 1968 Apr;52(4):869–889. [PMC free article] [PubMed] [Google Scholar]
  6. GELFAND M. CHRONIC URINARY SCHISTOSOMIASIS AND ITS RELATIONSHIP TO HYPERTENSIONS. Cent Afr J Med. 1964 Jan;10:1–8. [PubMed] [Google Scholar]
  7. GELFAND M. The blood pressure in advanced urinary bilharziasis. Cent Afr J Med. 1962 Feb;8:58–61. [PubMed] [Google Scholar]
  8. Gelfand M., Weinberg R. Early inflammatory changes in the kidney in bilharziasis of the lower urinary tract. J Trop Med Hyg. 1968 Nov;71(11):285–287. [PubMed] [Google Scholar]
  9. KENT N. H. COMPARATIVE IMMUNOCHEMISTRY OF LARVAL AND ADULT FROM OF SCHISTOSOMA MANSONI. Ann N Y Acad Sci. 1963 Dec 30;113:100–113. doi: 10.1111/j.1749-6632.1963.tb40661.x. [DOI] [PubMed] [Google Scholar]
  10. LAUFER A., TAL C., BEHAR A. J. Effect of adjuvant (Freund's type) and its components on the organs of various animal species; a comparative study. Br J Exp Pathol. 1959 Feb;40(1):1–7. [PMC free article] [PubMed] [Google Scholar]
  11. SAKAGUCHI H., DACHS S., GRISHMAN E., PARONETTO F., SALOMON M., CHURG J. HEPATIC GLOMERULOSCLEROSIS. AN ELECTRON MICROSCOPIC STUDY OF RENAL BIOPSIES IN LIVER DISEASES. Lab Invest. 1965 May;14:533–545. [PubMed] [Google Scholar]
  12. da Silva L. C., de Brito T., Camargo M. E., de Boni D. R., Lopes J. D., Gunji J. Kidney biopsy in the hepatosplenic form of infection with Schistosoma mansoni in man. Bull World Health Organ. 1970;42(6):907–910. [PMC free article] [PubMed] [Google Scholar]

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