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. 1972;47(2):139–150.

Geochemical environments, trace elements, and cardiovascular diseases

R Masironi, A T Miesch, M D Crawford, E I Hamilton
PMCID: PMC2480902  PMID: 4539410

Abstract

Cardiovascular diseases are often found to be associated with certain physicochemical characteristics of the environment—namely, the hardness of the water and the types of rock and soil underlying the area. Areas supplied with soft water usually have higher cardiovascular death rates than do areas supplied with hard water. Evidence linking cardiovascular diseases with the geochemistry of rocks and soils is more limited. The nature of these associations is still speculative but it is possible that certain trace elements are involved, some being beneficial and others harmful. Further epidemiological studies to identify these various trace elements are desirable.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson T. W., Le Riche W. H., MacKay J. S. Sudden death and ischemic heart disease. Correlation with hardness of local water supply. N Engl J Med. 1969 Apr 10;280(15):805–807. doi: 10.1056/NEJM196904102801504. [DOI] [PubMed] [Google Scholar]
  2. Anderson T. W., le Riche W. H. Sudden death from ischemic heart disease in ontario. Can Med Assoc J. 1971 Jul 24;105(2):155–160. [PMC free article] [PubMed] [Google Scholar]
  3. BOEN S. T., LEIJNSE B., GERBRANDY J. Influence of serum calcium concentration on QT-interval and circulation. Clin Chim Acta. 1962 May;7:432–436. doi: 10.1016/0009-8981(62)90045-1. [DOI] [PubMed] [Google Scholar]
  4. Bierenbaum M. L., Fleischman A. I., Dunn J. P., Belk H. D., Storter B. M. Serum lipids in hard and soft water communities. Isr J Med Sci. 1969 Jul-Aug;5(4):657–660. [PubMed] [Google Scholar]
  5. Biörck G., Boström H., Widström A. On the relationship between water hardness and death rate in cardiovascular diseases. Acta Med Scand. 1965 Aug;178(2):239–251. doi: 10.1111/j.0954-6820.1965.tb04267.x. [DOI] [PubMed] [Google Scholar]
  6. Boström H., Wester P. O. Trace elements in drinking water and death rate in cardiovascular disease. Acta Med Scand. 1967 Apr;181(4):465–473. doi: 10.1111/j.0954-6820.1967.tb07265.x. [DOI] [PubMed] [Google Scholar]
  7. Crawford M. D., Gardner M. J., Morris J. N. Changes in water hardness and local death-rates. Lancet. 1971 Aug 14;2(7720):327–329. doi: 10.1016/s0140-6736(71)90055-9. [DOI] [PubMed] [Google Scholar]
  8. Crawford M. D., Gardner M. J., Morris J. N. Mortality and hardness of local water-supplies. Lancet. 1968 Apr 20;1(7547):827–831. doi: 10.1016/s0140-6736(68)90297-3. [DOI] [PubMed] [Google Scholar]
  9. Crawford M. D., Morris J. N. Lead in drinking water. Lancet. 1967 Nov 18;2(7525):1087–1088. doi: 10.1016/s0140-6736(67)90364-9. [DOI] [PubMed] [Google Scholar]
  10. Crawford T., Crawford M. D. Prevalence and pathological changes of ischaemic heart-disease in a hard-water and in a soft-water area. Lancet. 1967 Feb 4;1(7484):229–232. doi: 10.1016/s0140-6736(67)91297-4. [DOI] [PubMed] [Google Scholar]
  11. Dudley E. F., Beldin R. A., Johnson B. C. Climate, water hardness and coronary heart disease. J Chronic Dis. 1969 Jun;22(1):25–48. doi: 10.1016/0021-9681(69)90084-8. [DOI] [PubMed] [Google Scholar]
  12. ELLIOTT G. B., ALEXANDER E. A. Sodium from drinking water as an unsuspected cause of cardiac decompensation. Circulation. 1961 Apr;23:562–566. doi: 10.1161/01.cir.23.4.562. [DOI] [PubMed] [Google Scholar]
  13. Fatula M. I. Chastota arterial'noi gipertonii sredi lits, upotrebliaiushchikh vodu s povyshennym soderzhaniem khoristogo natriia. Sov Med. 1967 May;30(5):134–136. [PubMed] [Google Scholar]
  14. Goldsmith N. F., Goldsmith J. R. Epidemiological aspects of magnesium and calcium metabolism. Implications of altered magnesium metabolism in women taking drugs for the suppression of ovulation. Arch Environ Health. 1966 May;12(5):607–619. doi: 10.1080/00039896.1966.10664441. [DOI] [PubMed] [Google Scholar]
  15. Hart J. T. The distribution of mortality from coronary heart disease in South Wales. J R Coll Gen Pract. 1970 May;19(94):258–268. [PMC free article] [PubMed] [Google Scholar]
  16. Häsänen E. Iodine content of drinking water and diseases of the circulatory system. Ann Med Exp Biol Fenn. 1970;48(2):117–121. [PubMed] [Google Scholar]
  17. Kamiyama S., Yamada F., Kobayashi S., Takahashi E. Comparative study on physical conditoion and blood chemistry of inhabitants in farm and fishing villages in relation to their difference in mortality from cerebrovascular disease. Tohoku J Exp Med. 1969 Jan;97(1):81–94. doi: 10.1620/tjem.97.81. [DOI] [PubMed] [Google Scholar]
  18. MORRIS J. N., CRAWFORD M. D., HEADY J. A. Hardness of local water-supplies and mortality from cardiovascular disease in the County Boroughs of England and Wales. Lancet. 1961 Apr 22;1(7182):860–862. doi: 10.1016/s0140-6736(61)90180-5. [DOI] [PubMed] [Google Scholar]
  19. Marzot G., Cenni P., Viscomi N., Poli L. D. Acqua e mortalità per vasculopatie ischemiche del miocardio. Ig Mod. 1968;61(11):895–908. [PubMed] [Google Scholar]
  20. Masironi R. Cardiovascular mortality in relation to radioactivity and hardness of local water supplies in the USA. Bull World Health Organ. 1970;43(5):687–697. [PMC free article] [PubMed] [Google Scholar]
  21. Masironi R. Trace elements and cardiovascular diseases. Bull World Health Organ. 1969;40(2):305–312. [PMC free article] [PubMed] [Google Scholar]
  22. Morton W. E. Hypertension and drinking water. A pilot statewide ecological study in Colorado. J Chronic Dis. 1971 Jan;23(8):537–545. doi: 10.1016/0021-9681(71)90129-9. [DOI] [PubMed] [Google Scholar]
  23. Neri L. C., Hewitt D., Mandel J. S. Risk of sudden death in soft water areas. Am J Epidemiol. 1971 Aug;94(2):101–104. doi: 10.1093/oxfordjournals.aje.a121300. [DOI] [PubMed] [Google Scholar]
  25. Peterson D. R., Thompson D. J., Nam J. M. Water hardness, arteriosclerotic heart disease and sudden death. Am J Epidemiol. 1970 Aug;92(2):90–93. doi: 10.1093/oxfordjournals.aje.a121189. [DOI] [PubMed] [Google Scholar]
  26. Raab W. Myocardial electrolyte derangement: crucial feature of pluricausal, so-called coronary, heart disease (dysionic cardiopathy). Ann N Y Acad Sci. 1969 Jul 30;147(17):627–686. doi: 10.1111/j.1749-6632.1969.tb41278.x. [DOI] [PubMed] [Google Scholar]
  27. Robertson J. S. Mortality and hardness of water. Lancet. 1968 Aug 10;2(7563):348–349. doi: 10.1016/s0140-6736(68)90552-7. [DOI] [PubMed] [Google Scholar]
  28. SCHROEDER H. A. Relation between mortality from cardiovascular disease and treated water supplies: variations in states and 163 largest municipalities of the United States. J Am Med Assoc. 1960 Apr 23;172:1902–1908. doi: 10.1001/jama.1960.03020170028007. [DOI] [PubMed] [Google Scholar]
  29. Sauer H. I., Payne G. H., Council C. R., Terrell J. C. Cardiovascular disease mortality patterns in Georgia and North Carolina. Public Health Rep. 1966 May;81(5):455–465. [PMC free article] [PubMed] [Google Scholar]
  30. Schroeder H. A. Municipal drinking water and cardiovascular death rates. JAMA. 1966 Jan 10;195(2):81–85. [PubMed] [Google Scholar]
  31. Schroeder H. A., Nason A. P., Balassa J. J. Trace metals in rat tissues as influenced by calcium in water. J Nutr. 1967 Nov;93(3):331–336. doi: 10.1093/jn/93.3.331. [DOI] [PubMed] [Google Scholar]
  32. Schroeder H. A. The water factor. N Engl J Med. 1969 Apr 10;280(15):836–838. doi: 10.1056/NEJM196904102801511. [DOI] [PubMed] [Google Scholar]
  33. Takahashi E. Geographic distribution of mortality rate from cerebrovascular disease in European countries. Tohoku J Exp Med. 1967 Aug;92(4):345–378. doi: 10.1620/tjem.92.345. [DOI] [PubMed] [Google Scholar]
  34. Voors A. W. Does lithium depletion cause atherosclerotic heart-disease? Lancet. 1969 Dec 20;2(7634):1337–1339. doi: 10.1016/s0140-6736(69)90868-x. [DOI] [PubMed] [Google Scholar]

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