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. 1970 Sep;103(3):616–621. doi: 10.1128/jb.103.3.616-621.1970

Differential Depression of Staphylococcal Plasmid and Chromosomal Penicillinase Genes by a Class of Unlinked Chromosomal Mutations (R2−)1

S Cohen a, E G Vernon a, H M Sweeney a
PMCID: PMC248135  PMID: 5474880

Abstract

We described previously a class of mutations (phenotypic designation R2−) in Staphylococcus aureus that were unlinked to penicillinase genes but nevertheless imposed constitutive synthesis of this enzyme upon wild-type plasmids. The plasmids affected by these mutations have been found to possess the same maintenance-compatibility type (I) and to form penicillinase of serotype A. Three plasmids that had a different maintenance-compatibility type (II) and formed penicillinase of serotype C were only slightly derepressed in R2− mutants. Three chromosomal penicillinase genes were variably derepressed, the range extending from negligible to nearly complete derepression. The differences in degree of derepression among the three types of penicillinase linkage groups were tentatively ascribed to position effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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