Skip to main content
PMC home page
Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1973;48(5):547–554.

Characterization of poliovirus isolates in Japan after the mass vaccination with live oral poliomyelitis vaccine (Sabin)*

Isamu Tagaya, Chieko Nakao, Minoru Hara, Shizuko Yamadera
PMCID: PMC2482930  PMID: 4359681

Abstract

From 1962 to 1968, 127 poliovirus isolates (92 from clinical specimens and 35 from healthy subjects) were subjected to intratypic serodifferentiation by the modified Wecker and McBride techniques. The two techniques gave concordant results for 103 strains, 91 of which were classified as vaccine-like, 9 as nonvaccine-like, and 3 as intermediate; 20 were classified as vaccine-like by one technique and as intermediate by the other, and 4 as nonvaccine-like by one technique and as intermediate by the other. The origin of the nonvaccine-like strains is unknown, but it is unlikely that they had been circulating in the community long. An rct/40-marker test of the isolates revealed a higher positivity rate than that found in field trials of Sabin vaccine. The results indicate that wild poliovirus has been almost completely eradicated from Japan.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Deibel R., Macdonald D. Serodifferentiation of type 3 poliovirus strains isolated 1960-1965 from patients and healthy vaccinees. Characterization of strains associated with disease in vaccinated persons and household contacts. Am J Epidemiol. 1968 Mar;87(2):396–410. doi: 10.1093/oxfordjournals.aje.a120830. [DOI] [PubMed] [Google Scholar]
  2. FURESZ J., ARMSTRONG R. E., MOREAU P., NAGLER F. P. GENETIC MARKERS OF POLIOVIRUS STRAINS ISOLATED FROM PARALYTIC PATIENTS PRIOR TO AND AFTER SABIN VACCINATION PROGRAMS. II. STUDIES ON TYPE 3 STRAINS. Am J Hyg. 1964 Jul;80:55–61. doi: 10.1093/oxfordjournals.aje.a120458. [DOI] [PubMed] [Google Scholar]
  3. FURESZ J., ARMSTRONG R. E., YAROSH W., NAGLER F. P. GENETIC MARKERS OF POLIOVIRUS STRAINS ISOLATED FROM PARALYTIC PATIENTS PRIOR TO AND AFTER SABIN VACCINATION PROGRAMS. I. STUDIES ON TYPE 1 STRAINS. Am J Hyg. 1964 Jul;80:45–54. doi: 10.1093/oxfordjournals.aje.a120457. [DOI] [PubMed] [Google Scholar]
  4. Furesz J., Armstrong R. E., Moreau P., Yarosh W., Nagler F. P. Antigenic studies on Sabin types 1 & 3 poliovaccine virus during 1 to 7 passages in the human intestinal tract. Am J Epidemiol. 1966 May;83(3):501–508. doi: 10.1093/oxfordjournals.aje.a120601. [DOI] [PubMed] [Google Scholar]
  5. Hopkins C. C., Dismukes W. E., Glick T. H., Warren R. J. Surveillance of paralytic poliomyelitis in the United States. 1966 and 1967 cases, and 1965-1967 cases associated with oral poliovirus vaccine. JAMA. 1969 Oct 27;210(4):694–700. [PubMed] [Google Scholar]
  6. Kitahara T., Hara M., Nakao C., Soda K., Tagaya I. Serodifferentiation of poliovirus strains. I. Modified Wecker test on types 1 and 2 poliovirus strains. Jpn J Med Sci Biol. 1967 Oct;20(5):349–376. doi: 10.7883/yoken1952.20.349. [DOI] [PubMed] [Google Scholar]
  7. McBRIDE W. D. Antigenic analysis of polioviruses by kinetic studies of serum neutralization. Virology. 1959 Jan;7(1):45–58. doi: 10.1016/0042-6822(59)90176-x. [DOI] [PubMed] [Google Scholar]
  8. NAKANO J. H., GELFAND H. M., COLE J. T. THE USE OF A MODIFIED WECKER TECHNIQUE FOR SERODIFFERENTIATION OF TYPE 1 POLIOVIRUSES RELATED AND UNRELATED TO SABIN'S VACCINE STRAIN. II. ANTIGENIC SEGREGATION OF ISOLATES FROM SPECIMENS COLLECTED IN FIELD STUDIES. Am J Hyg. 1963 Sep;78:214–226. doi: 10.1093/oxfordjournals.aje.a120339. [DOI] [PubMed] [Google Scholar]
  9. Nakano J. H., Cole J. T. Antigenic segregation of type 2 poliovirus isolants related and unrelated to Sabin's vaccine strain with modified Wecker technique. Am J Epidemiol. 1970 Mar;91(3):317–327. doi: 10.1093/oxfordjournals.aje.a121142. [DOI] [PubMed] [Google Scholar]
  10. Nakano J. H., Gelfand H. M., Cole J. T. Antigenic segregation of type 3 poliovirus isolates related and unrelated to Sabin's vaccine strain with the use of modified Wecker and McBride techniques. Am J Epidemiol. 1966 Jan;83(1):130–145. doi: 10.1093/oxfordjournals.aje.a120561. [DOI] [PubMed] [Google Scholar]
  11. Nakao C. Antigenic characterization of poliovirus strains by neutralization kinetic studies and the modified Wecker technique. Jpn J Med Sci Biol. 1969 Aug;22(4):217–233. doi: 10.7883/yoken1952.22.217. [DOI] [PubMed] [Google Scholar]
  12. Rocchi G., Santoro R., Marchegiani M. Antigenic characterization of poliovirus strains isolated in Italy (1964-1968) from vaccinated and unvaccinated patients. Ann Inst Pasteur (Paris) 1970 Feb;118(2):224–234. [PubMed] [Google Scholar]
  13. Soda K., Kitahara T., Nakao C., Hara M., Tagaya I. Serodifferentiation of poliovirus strains. II. Modified Wecker test on type 3 poliovirus strains. Jpn J Med Sci Biol. 1969 Aug;22(4):201–216. doi: 10.7883/yoken1952.22.201. [DOI] [PubMed] [Google Scholar]
  14. VONKA V., JANDA Z., SIMON J. The stability of the intratypic antigenic character of Sabin's type 1 attenuated virus (LSc-2ab). Arch Gesamte Virusforsch. 1962;12:7–16. doi: 10.1007/BF01258751. [DOI] [PubMed] [Google Scholar]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization

RESOURCES