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Journal of Bacteriology logoLink to Journal of Bacteriology
. 1971 Jan;105(1):232–240. doi: 10.1128/jb.105.1.232-240.1971

d-Mannitol Utilization in Salmonella typhimurium

David Berkowitz 1
PMCID: PMC248346  PMID: 4322346

Abstract

A biochemical and genetic analysis of d-mannitol metabolism in Salmonella typhimurium indicates that d-mannitol is phosphorylated by the phosphoenolpyruvate-dependent phosphotransferase system. d-Mannitol-1-phosphate is converted to d-fructose-6-phosphate by mannitol-1-phosphate dehydrogenase. Two classes of mannitol mutants are described. Both map at about 115 min on the Salmonella chromosome. Mutants missing mannitol-1-phosphate dehydrogenase activity are mannitol sensitive; i.e., either growth is inhibited or the cells are lysed in the presence of mannitol. In a strain missing adenyl cyclase activity, the mannitol genes require exogenous cyclic adenosine-3′,5′-monophosphate for expression.

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Selected References

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