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. 1971 Feb;105(2):519–522. doi: 10.1128/jb.105.2.519-522.1971

Inhibition of Growth of Salmonella typhimurium and of Threonine Deaminase and Transaminase B by β-Chloroalanine

Stuart M Arfin 1, David A Koziell 1
PMCID: PMC248412  PMID: 5541528

Abstract

β-Chloro-l-alanine (CA) was found to inhibit the growth of Salmonella typhimurium. The inhibition was overcome by isoleucine plus valine. CA inhibited the activity of threonine deaminase and transaminase B in vitro. The inhibition of threonine deaminase was reversible and was not affected by desensitization to isoleucine inhibition. Transaminase B was irreversibly inactivated. Derepression of some of the isoleucine and valine biosynthetic enzymes was achieved by growth of wild-type cells on low levels of CA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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