Skip to main content
NCBI home page
The Journal of the Canadian Chiropractic Association logoLink to The Journal of the Canadian Chiropractic Association
. 1988 Mar;32(1):23–27.

Calcium pyrophosphate dihydrate crystal deposition disease: A report of a case

Glynn Till, Silvano A Mior
PMCID: PMC2484460

Abstract

The nature of calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is reviewed and illustrated with a case report. CPPD is one of several calcium-containing crystals to be found in various pathological tissues which are associated with abnormal cellular localizations of proteoglycan. Clinically and radiologically it is an age-related disorder which resembles osteoarthritis and is sometimes interspersed with attacks of acute arthritis. Diagnostic and case management aspects of relevance to chiropractic are considered.

Keywords: CPPD, spinal stenosis, posterior column disease, chiropractic, manipulation

Full text

PDF
23

Images in this article

24Figure 1
on p.24
24Figure 2
on p.24
26Figure 3
on p.26

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berghausen E. J., Balogh K., Landis W. J., Lee D. D., Wright A. M. Cervical myelopathy attributable to pseudogout. Case report with radiologic, histologic, and crystallographic observations. Clin Orthop Relat Res. 1987 Jan;(214):217–221. [PubMed] [Google Scholar]
  2. Bjelle A. Pyrophosphate arthropathy. Scand J Rheumatol. 1979;8(3):145–153. doi: 10.3109/03009747909114447. [DOI] [PubMed] [Google Scholar]
  3. Cheung H. S., Halverson P. B., McCarty D. J. Release of collagenase, neutral protease, and prostaglandins from cultured mammalian synovial cells by hydroxyapatite and calcium pyrophosphate dihydrate crystals. Arthritis Rheum. 1981 Nov;24(11):1338–1344. doi: 10.1002/art.1780241102. [DOI] [PubMed] [Google Scholar]
  4. Eisenstein S. Measurements of the lumbar spinal canal in 2 racial groups. Clin Orthop Relat Res. 1976 Mar-Apr;(115):42–46. [PubMed] [Google Scholar]
  5. Fam A. G., Topp J. R., Stein H. B., Little A. H. Clinical and roentgenographic aspects of pseudogout: a study of 50 cases and a review. Can Med Assoc J. 1981 Mar 1;124(5):545–551. [PMC free article] [PubMed] [Google Scholar]
  6. Halverson P. B., McCarty D. J. Patterns of radiographic abnormalities associated with basic calcium phosphate and calcium pyrophosphate dihydrate crystal deposition in the knee. Ann Rheum Dis. 1986 Jul;45(7):603–605. doi: 10.1136/ard.45.7.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Howell D. S., Muniz O., Pita J. C., Enis J. E. Extrusion of pyrophosphate into extracellular media by osteoarthritic cartilage incubates. J Clin Invest. 1975 Dec;56(6):1473–1480. doi: 10.1172/JCI108228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McCarty D. J. Arthritis associated with crystals containing calcium. Med Clin North Am. 1986 Mar;70(2):437–454. doi: 10.1016/s0025-7125(16)30962-2. [DOI] [PubMed] [Google Scholar]
  9. McCarty D. J. Arthropathies associated with calcium-containing crystals. Hosp Pract (Off Ed) 1986 Oct 15;21(10):109-15, 118-20. [PubMed] [Google Scholar]
  10. McCarty D. J., Cheung H. S. Prostaglandin (PG) E2 generation by cultured canine synovial fibroblasts exposed to microcrystals containing calcium. Ann Rheum Dis. 1985 May;44(5):316–320. doi: 10.1136/ard.44.5.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McCarty D. Crystals, joints, and consternation. Ann Rheum Dis. 1983 Jun;42(3):243–253. doi: 10.1136/ard.42.3.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Milazzo S. C. Chondrocalcinosis and other crystal induced arthropathies. Aust N Z J Med. 1978;8 (Suppl 1):152–154. doi: 10.1111/j.1445-5994.1978.tb04811.x. [DOI] [PubMed] [Google Scholar]
  13. Riestra J. L., Sánchez A., Rodríques-Valverde V., Castillo E., Calderón J. Roentgenographic features of the arthropathy associated with CPPD crystal deposition disease. A comparative study with primary osteoarthritis. J Rheumatol. 1985 Dec;12(6):1154–1158. [PubMed] [Google Scholar]
  14. Ryan L. M., Cheung H. S., McCarty D. J. Release of pyrophosphate by normal mammalian articular hyaline and fibrocartilage in organ culture. Arthritis Rheum. 1981 Dec;24(12):1522–1527. doi: 10.1002/art.1780241211. [DOI] [PubMed] [Google Scholar]
  15. Silcox D. C., McCarty D. J., Jr Elevated inorganic pyrophosphate concentrations in synovial fluids in osteoarthritis and pseudogout. J Lab Clin Med. 1974 Apr;83(4):518–531. [PubMed] [Google Scholar]
  16. Wyke B. Cervical articular contribution to posture and gait: their relation to senile disequilibrium. Age Ageing. 1979 Nov;8(4):251–258. [PubMed] [Google Scholar]

Articles from The Journal of the Canadian Chiropractic Association are provided here courtesy of The Canadian Chiropractic Association

RESOURCES