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. 1989 Apr;63(4):1803–1807. doi: 10.1128/jvi.63.4.1803-1807.1989

Induction of nephroblastoma by myeloblastosis-associated virus type 1: state of proviral DNAs in tumor cells.

J Soret 1, G Dambrine 1, B Perbal 1
PMCID: PMC248450  PMID: 2564440

Abstract

Myeloblastosis-associated virus type 1 (MAV1) derived from a molecular clone of infectious proviral DNA (B. Perbal, J. S. Lipsick, J. Svoboda, R. F. Silva, and M. A. Baluda, J. Virol. 56:240-244, 1985) was shown to specifically induce nephroblastoma in chickens and therefore belongs to the MAV-N class. We show that nephroblastomas are polyclonal tumors containing rearranged proviral genomes. Rearrangements occur preferentially in the gag-pol region of the MAV1 proviral genome, and similar rearrangements can be detected in well-developed independent tumors.

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Selected References

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