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. 1990 Nov;64(11):5457–5464. doi: 10.1128/jvi.64.11.5457-5464.1990

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes.

S Jonjić 1, I Pavić 1, P Lucin 1, D Rukavina 1, U H Koszinowski 1
PMCID: PMC248597  PMID: 1976821

Abstract

Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain conditions the CD8+ T-lymphocyte subset can be dispensable for clearance of cytomegalovirus. Mice depleted of the CD8+ T-lymphocyte subset eliminated infectious virus with a clearance kinetics similar to that of normal mice. Adoptive transfer studies revealed that the limitation of virus spread required the cooperation between the CD4+ subset and other cells. Comparison between protective functions generated in fully immunocompetent and in CD8- mice demonstrated that elimination of the CD8+ subset before infection altered the quality of the antiviral immune response. The compensatory protective activity gained by CD4+ cells in CD8- mice was absent in normal mice recovering from virus infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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