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. 1990 Nov;64(11):5649–5651. doi: 10.1128/jvi.64.11.5649-5651.1990

Association of simian virus 40 small-t antigen with the 61-kilodalton component of a cellular protein complex.

B Joshi 1, K Rundell 1
PMCID: PMC248622  PMID: 2170691

Abstract

Two cellular proteins, 61 and 37 kDa, are found in association with the simian virus 40 (SV40) small-t antigen. Fractionation in standard chromatography systems showed that these proteins were associated with one another in uninfected cells, suggesting that the small-t antigen may bind the complex as a whole and not each individual protein independently. In the presence of N-ethylmaleimide, the 37-kDA protein was selectively released from immune complexes, leaving the small-t antigen and 61-kDa protein in association. This result suggests that the small-t antigen may bind only the 61-kDa protein and that the 37-kDa protein may be associated with immune complexes by virtue of its association with the 61-kDa cellular protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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