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. 1995;73(2):199–205.

Impact of combined large-scale ivermectin distribution and vector control on transmission of Onchocerca volvulus in the Niger basin, Guinea.

P Guillet 1, A Sékétéli 1, E S Alley 1, H Agoua 1, B A Boatin 1, Y Bissan 1, L K Akpoboua 1, D Quillévéré 1, E M Samba 1
PMCID: PMC2486755  PMID: 7743591

Abstract

As part of the WHO Onchocerciasis Control Programme in West Africa (OCP), the attack phase of operations in the Niger basin in Guinea began in 1989 with the simultaneous use of ivermectin and vector control. Larvicide applications coupled with annual large-scale ivermectin distribution have greatly reduced blackfly infectivity (by 78.8% for the number of infective larvae per 1000 parous flies). The combination of vector control and ivermectin has permitted excellent control of transmission. In the original OCP area, it took 6-8 years of vector control alone to obtain an equivalent decrease in blackfly infectivity. For the same number of flies caught, transmission was much higher in areas where ivermectin had not been distributed. The combined use of ivermectin and vector control has opened up new prospects for carrying out OCP operations with, notably, the possibility of reducing larviciding operations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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