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. 1996;74(2):181–187.

A predictable comeback: the second pandemic of infections caused by Neisseria meningitidis serogroup A subgroup III in Africa, 1995.

J Y Riou 1, S Djibo 1, L Sangare 1, J P Lombart 1, P Fagot 1, J P Chippaux 1, M Guibourdenche 1
PMCID: PMC2486908  PMID: 8706234

Abstract

Between 14 January and 4 April 1995 we isolated and characterized 44 meningococcal strains in Cameroon, Chad, Niger, and Burkina Faso; among these was the strain A:4:P1.9/clone III-1, which was involved in the second meningitis pandemic. This isolate was found in the clonal form in Niger and strains of the ET-37 complex were also found in the other three study countries, but apparently did not cause epidemics. One strain (Y:2a:P1.2,5 (ET-37 complex)) was isolated in January 1995 and another (A:4:P1.9) in March 1995 in Garoua (Cameroon). Eight strains were isolated in Moundou (Chad) between January and April 1995: the A:4:P1.9/clone III-1 (1 strain); members of the ET-37 complex (Y:2a:P1.2,5 (4 strains), Y:NT:P1.2,5 (1 strain), and Y:2a:-(1 strain)); and serogroup X (1 strain). In Niger, 31 strains were isolated between February and April 1995 from different regions. All were A:4:P1.9/clone III-1; between November 1994 and April 1995 there were 23814 cases of meningitis reported of which 2227 resulted in death. Three strains were isolated in Burkina Faso in April 1995: two were Y:2a:P1.2,5 (ET-37 complex) and one was A:4:P1.9/clone III-1. Thus in 1995 the epidemic and invasive strain (A:4:P1.9/clone III-1) responsible for the second pandemic was present in the four countries (Cameroon, Chad, Niger and Burkino Faso) that make up the area frequently affected by such epidemics and where cases are generally reported during the dry season.

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Selected References

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  1. Ashton F. E., Ryan J. A., Borczyk A., Caugant D. A., Mancino L., Huang D. Emergence of a virulent clone of Neisseria meningitidis serotype 2a that is associated with meningococcal group C disease in Canada. J Clin Microbiol. 1991 Nov;29(11):2489–2493. doi: 10.1128/jcm.29.11.2489-2493.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Caugant D. A., Zollinger W. D., Mocca L. F., Frasch C. E., Whittam T. S., Frøholm L. O., Selander R. K. Genetic relationships and clonal population structure of serotype 2 strains of Neisseria meningitidis. Infect Immun. 1987 Jun;55(6):1503–1512. doi: 10.1128/iai.55.6.1503-1512.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Greenwood B. M., Wali S. S. Control of meningococcal infection in the African meningitis belt by selective vaccination. Lancet. 1980 Apr 5;1(8171):729–732. doi: 10.1016/s0140-6736(80)91230-1. [DOI] [PubMed] [Google Scholar]
  4. Guibourdenche M., Caugant D. A., Hervé V., Debonne J. M., Lanckriet C., Merlin M., Mathiot C., Roungou J. B., Martet G., Riou J. Y. Characteristics of serogroup A Neisseria meningitidis strains isolated in the Central African Republic in February 1992. Eur J Clin Microbiol Infect Dis. 1994 Feb;13(2):174–177. doi: 10.1007/BF01982194. [DOI] [PubMed] [Google Scholar]
  5. Haimanot R. T., Caugant D. A., Fekadu D., Bjune G., Belete B., Frøholm L. O., Høiby E. A., Rosenqvist E., Selander R. K., Bjorvatn B. Characteristics of serogroup A Neisseria meningitidis responsible for an epidemic in Ethiopia, 1988-89. Scand J Infect Dis. 1990;22(2):171–174. doi: 10.3109/00365549009037898. [DOI] [PubMed] [Google Scholar]
  6. Harrison L. H. The worldwide prevention of meningococcal infection. Still an elusive goal. JAMA. 1995 Feb 1;273(5):419–421. [PubMed] [Google Scholar]
  7. Jones D. M., Sutcliffe E. M. Group A meningococcal disease in England associated with the Haj. J Infect. 1990 Jul;21(1):21–25. doi: 10.1016/0163-4453(90)90577-u. [DOI] [PubMed] [Google Scholar]
  8. Moore P. S., Harrison L. H., Telzak E. E., Ajello G. W., Broome C. V. Group A meningococcal carriage in travelers returning from Saudi Arabia. JAMA. 1988 Nov 11;260(18):2686–2689. [PubMed] [Google Scholar]
  9. Moore P. S. Meningococcal meningitis in sub-Saharan Africa: a model for the epidemic process. Clin Infect Dis. 1992 Feb;14(2):515–525. doi: 10.1093/clinids/14.2.515. [DOI] [PubMed] [Google Scholar]
  10. Moore P. S., Reeves M. W., Schwartz B., Gellin B. G., Broome C. V. Intercontinental spread of an epidemic group A Neisseria meningitidis strain. Lancet. 1989 Jul 29;2(8657):260–263. doi: 10.1016/s0140-6736(89)90439-x. [DOI] [PubMed] [Google Scholar]
  11. Morelli G., del Valle J., Lammel C. J., Pohlner J., Müller K., Blake M., Brooks G. F., Meyer T. F., Koumaré B., Brieske N. Immunogenicity and evolutionary variability of epitopes within IgA1 protease from serogroup A Neisseria meningitidis. Mol Microbiol. 1994 Jan;11(1):175–187. doi: 10.1111/j.1365-2958.1994.tb00299.x. [DOI] [PubMed] [Google Scholar]
  12. Olyhoek T., Crowe B. A., Achtman M. Clonal population structure of Neisseria meningitidis serogroup A isolated from epidemics and pandemics between 1915 and 1983. Rev Infect Dis. 1987 Jul-Aug;9(4):665–692. doi: 10.1093/clinids/9.4.665. [DOI] [PubMed] [Google Scholar]
  13. Pinner R. W., Onyango F., Perkins B. A., Mirza N. B., Ngacha D. M., Reeves M., DeWitt W., Njeru E., Agata N. N., Broome C. V. Epidemic meningococcal disease in Nairobi, Kenya, 1989. The Kenya/Centers for Disease Control (CDC) Meningitis Study Group. J Infect Dis. 1992 Aug;166(2):359–364. doi: 10.1093/infdis/166.2.359. [DOI] [PubMed] [Google Scholar]
  14. Poolman J. T., Abdillahi H. Outer membrane protein serosubtyping of Neisseria meningitidis. Eur J Clin Microbiol Infect Dis. 1988 Apr;7(2):291–292. doi: 10.1007/BF01963104. [DOI] [PubMed] [Google Scholar]
  15. Selander R. K., Caugant D. A., Ochman H., Musser J. M., Gilmour M. N., Whittam T. S. Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics. Appl Environ Microbiol. 1986 May;51(5):873–884. doi: 10.1128/aem.51.5.873-884.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Vandekerkove M., Bradstreet P., Faucon R., Benech S. Milieu de transport pour méningocoques. Ann Inst Pasteur (Paris) 1967 Aug;113(2):260–263. [PubMed] [Google Scholar]
  17. Wang J. F., Caugant D. A., Li X., Hu X., Poolman J. T., Crowe B. A., Achtman M. Clonal and antigenic analysis of serogroup A Neisseria meningitidis with particular reference to epidemiological features of epidemic meningitis in the People's Republic of China. Infect Immun. 1992 Dec;60(12):5267–5282. doi: 10.1128/iai.60.12.5267-5282.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wang J. F., Caugant D. A., Morelli G., Koumaré B., Achtman M. Antigenic and epidemiologic properties of the ET-37 complex of Neisseria meningitidis. J Infect Dis. 1993 Jun;167(6):1320–1329. doi: 10.1093/infdis/167.6.1320. [DOI] [PubMed] [Google Scholar]

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