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. 1997;75(4):349–354.

Fréquence de l'hépatite sporadique E en Côte d'Ivoire, vue au travers d'une sérologie encore problématique.

Incidence of sporadic hepatitis E in Ivory Coast based on still problematic serology

M Rioche 1, P Dubreuil 1, A Kouassi-Samgare 1, V Akran 1, P Nordmann 1, J Pillot 1
PMCID: PMC2486972  PMID: 9377791

Abstract

The first well-documented outbreak of viral hepatitis E in Africa was described in 1986 in Côte d'lvoire. Subsequently, no other outbreaks have been observed in the country. Côte d'lvoire therefore offers an excellent opportunity to evaluate the prevalence of sporadic viral hepatitis E in a country where the frequency of non-A, non-B, non-C viral hepatitis appears to be high. The study was carried out in Abidjan, the most populous city, and involved 111 hospitalized patients suffering from non-A, non-B and presumed non-C acute viral hepatitis. Screening for leptospirosis or a toxic etiology was carried out and the risk of including such patients eliminated. Diagnosis of viral hepatitis A was excluded from the absence of IgM anti-HAV antibodies. Patients with HBsAg and anti-HCV antibodies were not included in the study, although co-infection in asymptomatic HBV carriers or subsequent infection in patients who had recovered from a past HCV infection remained possible. There was a risk that some patients with late appearance of anti-HCV antibodies were included since PCR tests could not be performed. Cytomegalovirus or Epstein-Barr virus was not involved, since no specific IgMs against these viruses were detectable. Large discrepancies between the two commercial enzyme-linked immunosorbent assays (ELISAs) available for serological diagnosis of hepatitis E (Abbott and Genelabs) were observed. Among the 53 sera screened using both tests, only 20 gave positive results in both, and all such sera were confirmed using a domestic immunological test involving inhibition of labelled, well-documented anti-HEV-specific human IgG. Immunological confirmation was obtained for only half of the sera with discordant results in the commercial ELISAs. Full agreement between both commercial tests was observed for only 59% of the sera studied. The minimal incidence of sporadic viral hepatitis E among hospitalized patients in Abidjan with an acute hepatitis was estimated to be 27%.

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Selected References

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  1. Aggarwal R., Naik S. R. Hepatitis E: intrafamilial transmission versus waterborne spread. J Hepatol. 1994 Nov;21(5):718–723. doi: 10.1016/s0168-8278(94)80229-7. [DOI] [PubMed] [Google Scholar]
  2. Arankalle V. A., Tsarev S. A., Chadha M. S., Alling D. W., Emerson S. U., Banerjee K., Purcell R. H. Age-specific prevalence of antibodies to hepatitis A and E viruses in Pune, India, 1982 and 1992. J Infect Dis. 1995 Feb;171(2):447–450. doi: 10.1093/infdis/171.2.447. [DOI] [PubMed] [Google Scholar]
  3. Bradley D. W. Hepatitis E virus: a brief review of the biology, molecular virology, and immunology of a novel virus. J Hepatol. 1995;22(1 Suppl):140–145. [PubMed] [Google Scholar]
  4. Halfon P., Ouzan D., Chanas M., Khiri H., Feryn J. M., Mangin L., Masseyef M. F., Salvadori J. M. High prevalence of hepatitis E virus antibody in haemodialysis patients. Lancet. 1994 Sep 10;344(8924):746–746. doi: 10.1016/s0140-6736(94)92232-2. [DOI] [PubMed] [Google Scholar]
  5. Huang R., Nakazono N., Ishii K., Kawamata O., Kawaguchi R., Tsukada Y. Existing variations on the gene structure of hepatitis E virus strains from some regions of China. J Med Virol. 1995 Dec;47(4):303–308. doi: 10.1002/jmv.1890470403. [DOI] [PubMed] [Google Scholar]
  6. Koshy A., Richards A. L., al-Mufti S., Grover S., Shabrawy M. A., Pacsa A., al-Anezi H., al-Nakib B., Burans J., Carl M. Acute sporadic hepatitis E in Kuwait. J Med Virol. 1994 Apr;42(4):405–408. doi: 10.1002/jmv.1890420413. [DOI] [PubMed] [Google Scholar]
  7. Köksal I., Aydin K., Kardes B., Turgut H., Murt F. The role of hepatitis E virus in acute sporadic non-A, non-B hepatitis. Infection. 1994 Nov-Dec;22(6):407–410. doi: 10.1007/BF01715498. [DOI] [PubMed] [Google Scholar]
  8. Lavanchy D., Morel B., Frei P. C. Seroprevalence of hepatitis E virus in Switzerland. Lancet. 1994 Sep 10;344(8924):747–748. doi: 10.1016/s0140-6736(94)92235-7. [DOI] [PubMed] [Google Scholar]
  9. Linnen J., Wages J., Jr, Zhang-Keck Z. Y., Fry K. E., Krawczynski K. Z., Alter H., Koonin E., Gallagher M., Alter M., Hadziyannis S. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science. 1996 Jan 26;271(5248):505–508. doi: 10.1126/science.271.5248.505. [DOI] [PubMed] [Google Scholar]
  10. Nandwani R. Hepatitis E virus and HIV infection in homosexual men. Lancet. 1995 Jan 14;345(8942):126–127. doi: 10.1016/s0140-6736(95)90091-8. [DOI] [PubMed] [Google Scholar]
  11. Pillot J., Dubreuil P. Are blotting tests (Riba, western-blot ...) still useful as markers of hepatitis C virus infection? J Hepatol. 1995 Jul;23(1):103–105. doi: 10.1016/0168-8278(95)80320-3. [DOI] [PubMed] [Google Scholar]
  12. Pillot J., Favorov M. O., Grangeot-Keros L., Lazizi Y., Frydman R. Prévalence des anticorps anti-virus de l'hépatite E chez la femme enceinte, en région parisienne: considérations sérologiques. Presse Med. 1995 Sep 23;24(27):1271–1271. [PubMed] [Google Scholar]
  13. Pillot J., Türkoglu S., Dubreuil P., Cosson A., Lemaigre G., Meng J., Lazizi Y. Cross-reactive immunity against different strains of the hepatitis E virus transferable by simian and human sera. C R Acad Sci III. 1995 Oct;318(10):1059–1064. [PubMed] [Google Scholar]
  14. Rioche M., Himmich H., Cherkaoui A., Mourid A., Dubreuil P., Zahraoui M., Pillot J. Forte incidence des hépatites non-A, non-B sporadiques au Maroc: étude épidémiologique. Bull Soc Pathol Exot. 1991;84(2):117–127. [PubMed] [Google Scholar]
  15. Tsarev S. A., Tsareva T. S., Emerson S. U., Kapikian A. Z., Ticehurst J., London W., Purcell R. H. ELISA for antibody to hepatitis E virus (HEV) based on complete open-reading frame-2 protein expressed in insect cells: identification of HEV infection in primates. J Infect Dis. 1993 Aug;168(2):369–378. doi: 10.1093/infdis/168.2.369. [DOI] [PubMed] [Google Scholar]
  16. Turkoglu S., Lazizi Y., Meng H., Kordosi A., Dubreuil P., Crescenzo B., Benjelloun S., Nordmann P., Pillot J. Detection of hepatitis E virus RNA in stools and serum by reverse transcription-PCR. J Clin Microbiol. 1996 Jun;34(6):1568–1571. doi: 10.1128/jcm.34.6.1568-1571.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Yarbough P. O., Tam A. W., Fry K. E., Krawczynski K., McCaustland K. A., Bradley D. W., Reyes G. R. Hepatitis E virus: identification of type-common epitopes. J Virol. 1991 Nov;65(11):5790–5797. doi: 10.1128/jvi.65.11.5790-5797.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]

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