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. 1971 Jun;106(3):972–982. doi: 10.1128/jb.106.3.972-982.1971

Biochemical Bases for the Antimetabolite Action of l-Serine Hydroxamate

Tetsuya Tosa a,1, Lewis I Pizer a
PMCID: PMC248741  PMID: 4934072

Abstract

The amino acid analogue l-serine hydroxamate, which is bacteriostatic for Escherichia coli, has been shown to inhibit protein synthesis. The antimetabolite is a competitive inhibitor of seryl-transfer ribonucleic acid (tRNA) synthetase with a Ki value of 30 μm. Mutants resistant to l-serine hydroxamate have been selected, and three were shown to have seryl-tRNA synthetases with increased Ki values. One mutant contains a 3-phosphoglycerate dehydrogenase which is insensitive to inhibition by l-serine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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