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. 1990 Dec;64(12):6325–6328. doi: 10.1128/jvi.64.12.6325-6328.1990

Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice.

P A Offit 1, K I Dudzik 1
PMCID: PMC248814  PMID: 1978734

Abstract

Suckling mice are protected against murine rotavirus-induced gastroenteritis after adoptive transfer of splenic lymphocytes from immunized animals. Adoptive transfer of Thy1(+)-depleted or CD8(+)-depleted lymphocytes abrogated protection against challenge. (We previously found that depletion of Thy1+ or CD8+ lymphocytes from rotavirus-immunized mice decreased rotavirus-specific cytotoxic activity in vitro.) Protection against disease occurred in the absence of rotavirus-specific neutralizing antibodies in the sera of suckling mice. Rotavirus-specific cytotoxic T lymphocytes may be important in either amelioration of acute infection or protection against reinfection.

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Selected References

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