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. 1990 Dec;64(12):6345–6348. doi: 10.1128/jvi.64.12.6345-6348.1990

Strains from both Theiler's virus subgroups encode a determinant for demyelination.

J Fu 1, M Rodriguez 1, R P Roos 1
PMCID: PMC248818  PMID: 2243399

Abstract

The GDVII strain and other members of the GDVII subgroup of Theiler's murine encephalomyelitis viruses (TMEV) cause an acute lethal neuronal infection in mice, whereas the DA strain and other members of the TO subgroup of TMEV cause a chronic demyelinating disease associated with a persistent virus infection. We used GDVII/DA chimeric infectious cDNAs to produce intratypic recombinant viruses in order to clarify reasons for the TMEV subgroup-specific difference in demyelinating activity. We found that both the GDVII and DA strains contain a genetic determinant(s) for demyelinating activity. No demyelination occurs following GDVII strain inoculation because this strain produces an early neuronal disease that kills mice before white matter disease and persistent infection can occur.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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