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. 1991 Sep;65(9):5073–5079. doi: 10.1128/jvi.65.9.5073-5079.1991

Localization of immunogenic domains in the human immunodeficiency virus type 2 envelope.

M L Huang 1, M Essex 1, T H Lee 1
PMCID: PMC248972  PMID: 1714524

Abstract

Highly immunogenic domains have not yet been defined in the extracellular protein of the human immunodefiency virus type 2 (HIV-2) envelope. In this study, six contiguous segments covering the entire HIV-2ST envelope were amplified and cloned into a bacterial expression vector to localize the relative immunogenic reactivity of different regions of the molecule by Western blot (immunoblot) analysis. Our results demonstrate that the extracellular protein of the HIV-2 envelope contains highly immunogenic epitopes with potential value as type-specific markers for HIV-2 infection.

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Selected References

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