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. 1991 Sep;65(9):5102–5104. doi: 10.1128/jvi.65.9.5102-5104.1991

The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon.

B L Jacobs 1, R E Ferguson 1
PMCID: PMC248978  PMID: 1870214

Abstract

Replication of the Dearing strain of reovirus serotype 3 in mouse L cells was decreased 17- to 100-fold when a saturating dose of beta interferon (1,000 IU/ml) was used. Replication of the Lang strain of reovirus serotype 1 was inhibited only two- to threefold under similar conditions. It therefore appears that closely related strains of reovirus differ in their sensitivities to beta interferon treatment of mouse L cells.

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Selected References

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  1. Huismans H., Joklik W. K. Reovirus-coded polypeptides in infected cells: isolation of two native monomeric polypeptides with affinity for single-stranded and double-stranded RNA, respectively. Virology. 1976 Apr;70(2):411–424. doi: 10.1016/0042-6822(76)90282-8. [DOI] [PubMed] [Google Scholar]
  2. Imani F., Jacobs B. L. Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7887–7891. doi: 10.1073/pnas.85.21.7887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Kitajewski J., Schneider R. J., Safer B., Munemitsu S. M., Samuel C. E., Thimmappaya B., Shenk T. Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase. Cell. 1986 Apr 25;45(2):195–200. doi: 10.1016/0092-8674(86)90383-1. [DOI] [PubMed] [Google Scholar]
  4. Muñoz A., Carrasco L. Action of human lymphoblastoid interferon on HeLa cells infected with RNA-containing animal viruses. J Gen Virol. 1984 Feb;65(Pt 2):377–390. doi: 10.1099/0022-1317-65-2-377. [DOI] [PubMed] [Google Scholar]
  5. Nilsen T. W., Maroney P. A., Baglioni C. Synthesis of (2'-5')oligoadenylate and activation of an endoribonuclease in interferon-treated HeLa cells infected with reovirus. J Virol. 1982 Jun;42(3):1039–1045. doi: 10.1128/jvi.42.3.1039-1045.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. O'Malley R. P., Mariano T. M., Siekierka J., Mathews M. B. A mechanism for the control of protein synthesis by adenovirus VA RNAI. Cell. 1986 Feb 14;44(3):391–400. doi: 10.1016/0092-8674(86)90460-5. [DOI] [PubMed] [Google Scholar]
  7. Paez E., Esteban M. Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system. Virology. 1984 Apr 15;134(1):12–28. doi: 10.1016/0042-6822(84)90268-x. [DOI] [PubMed] [Google Scholar]
  8. Pestka S., Langer J. A., Zoon K. C., Samuel C. E. Interferons and their actions. Annu Rev Biochem. 1987;56:727–777. doi: 10.1146/annurev.bi.56.070187.003455. [DOI] [PubMed] [Google Scholar]
  9. Rice A. P., Kerr I. M. Interferon-mediated, double-stranded RNA-dependent protein kinase is inhibited in extracts from vaccinia virus-infected cells. J Virol. 1984 Apr;50(1):229–236. doi: 10.1128/jvi.50.1.229-236.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Samuel C. E., Duncan R., Knutson G. S., Hershey J. W. Mechanism of interferon action. Increased phosphorylation of protein synthesis initiation factor eIF-2 alpha in interferon-treated, reovirus-infected mouse L929 fibroblasts in vitro and in vivo. J Biol Chem. 1984 Nov 10;259(21):13451–13457. [PubMed] [Google Scholar]
  11. Samuel C. E., Knutson G. S. Mechanism of interferon action: human leukocyte and immune interferons regulate the expression of different genes and induce different antiviral states in human amnion U cells. Virology. 1983 Oct 30;130(2):474–484. doi: 10.1016/0042-6822(83)90101-0. [DOI] [PubMed] [Google Scholar]
  12. Samuel C. E. Mechanisms of the antiviral action of interferons. Prog Nucleic Acid Res Mol Biol. 1988;35:27–72. doi: 10.1016/s0079-6603(08)60609-1. [DOI] [PubMed] [Google Scholar]
  13. Simon E. H., Kung S., Koh T. T., Brandman P. Interferon-sensitive mutants of mengovirus. I. Isolation and biological characterization. Virology. 1976 Feb;69(2):727–736. doi: 10.1016/0042-6822(76)90501-8. [DOI] [PubMed] [Google Scholar]
  14. Su Y. H., Oakes J. E., Lausch R. N. Ocular avirulence of a herpes simplex virus type 1 strain is associated with heightened sensitivity to alpha/beta interferon. J Virol. 1990 May;64(5):2187–2192. doi: 10.1128/jvi.64.5.2187-2192.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Whitaker-Dowling P., Youngner J. S. Characterization of a specific kinase inhibitory factor produced by vaccinia virus which inhibits the interferon-induced protein kinase. Virology. 1984 Aug;137(1):171–181. doi: 10.1016/0042-6822(84)90020-5. [DOI] [PubMed] [Google Scholar]
  16. Whitaker-Dowling P., Youngner J. S. Vaccinia rescue of VSV from interferon-induced resistance: reversal of translation block and inhibition of protein kinase activity. Virology. 1983 Nov;131(1):128–136. doi: 10.1016/0042-6822(83)90539-1. [DOI] [PubMed] [Google Scholar]
  17. Wiebe M. E., Joklik T. W. The mechanism of inhibition of reovirus replication by interferon. Virology. 1975 Jul;66(1):229–240. doi: 10.1016/0042-6822(75)90193-2. [DOI] [PubMed] [Google Scholar]

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