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. 1991 Oct;65(10):5549–5552. doi: 10.1128/jvi.65.10.5549-5552.1991

Moloney leukemia virus immortalizes B lymphocytes in vitro.

J Runnels 1, L Serunian 1, M Thursby 1, N Rosenberg 1
PMCID: PMC249058  PMID: 1895405

Abstract

An in vitro culture system in which Moloney murine leukemia virus induces immortalization of mature B lymphocytes has been developed. The cell lines derived in this way are nontumorigenic, and virus production is not required to sustain them. This system provides a new in vitro model with which to study the stepwise process of transformation by retroviruses lacking oncogenes.

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Selected References

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