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. 1991 Oct;65(10):5558–5563. doi: 10.1128/jvi.65.10.5558-5563.1991

The Epstein-Barr virus BNLF-1 membrane protein LMP1 induces homotypic adhesion mediated by CD11a/CD18 in a murine B-cell line, mimicking the action of phorbol ester.

R Salcedo 1, S M Fuerstenberg 1, M Patarroyo 1, G Winberg 1
PMCID: PMC249062  PMID: 1680199

Abstract

Expression of the Epstein-Barr virus BNLF1 gene (LMP1) or treatment with 4B-phorbol-12,13-dibutyrate in the murine pro-B-cell line A/J-95 leads to a five- to sevenfold enhancement of homotypic adhesion without significant changes in adhesion molecule expression. Antibody to CD11a inhibits aggregation, indicating that CD11a/CD18-mediated adhesion is a common target for both agents.

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Selected References

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