Abstract
Fansimef is a combination of 250 mg mefloquine (base), 500 mg sulfadoxine, and 25 mg pyrimethamine per tablet. One hundred and fifty adult male Brazilian patients at Belém (Pará), who had peripheral blood smears positive for Plasmodium falciparum, with or without clinical symptoms of falciparum malaria, were treated in a double-blind randomized fashion with either one, two or three tablets of Fansimef. Of those receiving one tablet (48 patients), 81% were cured and 19% exhibited RI recrudescences. All the patients receiving two or three tablets of Fansimef (49 patients in each group) were cured. The rates of initial clearance of parasitaemia and fever were similar in all treatment groups. Tolerance was good at all dose levels. The main side-effects included nausea, vomiting, dizziness, diarrhoea and abdominal pain, but these were mild and transient and required no specific treatment. The incidence of vomiting and nausea was highest in patients given the three-tablet dose. The results of various haematological, biochemical and urine analyses were not adversely altered by the administration of Fansimef.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Doberstyn E. B., Phintuyothin P., Noeypatimanondh S., Teerakiartkamjorn C. Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine. Bull World Health Organ. 1979;57(2):275–279. [PMC free article] [PubMed] [Google Scholar]
- Ekue J. M., Simooya O. O., Sheth U. K., Wernsdorfer W. H., Njelesani E. K. A double-blind clinical trial of a combination of mefloquine, sulfadoxine and pyrimethamine in symptomatic falciparum malaria. Bull World Health Organ. 1985;63(2):339–343. [PMC free article] [PubMed] [Google Scholar]
- Kazim M., Puri S. K., Dutta G. P. Chemotherapeutic studies with mefloquine and selection of a mefloquine resistant strain of Plasmodium berghei. Indian J Med Res. 1979 Dec;70 (Suppl):95–102. [PubMed] [Google Scholar]
- Kofi Ekue J. M., Ulrich A. M., Rwabwogo-Atenyi J., Sheth U. K. A double-blind comparative clinical trial of mefloquine and chloroquine in symptomatic falciparum malaria. Bull World Health Organ. 1983;61(4):713–718. [PMC free article] [PubMed] [Google Scholar]