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Journal of Virology logoLink to Journal of Virology
. 1990 Jan;64(1):445–449. doi: 10.1128/jvi.64.1.445-449.1990

Expression of the herpes simplex virus type 1 glycoprotein C gene requires sequences in the 5' noncoding region of the gene.

J P Weir 1, P R Narayanan 1
PMCID: PMC249124  PMID: 2152831

Abstract

The role of the 5' noncoding region of the herpes simplex virus type 1 glycoprotein C (gC) gene in viral gene expression was investigated with recombinant herpesviruses that contained the bacterial beta-galactosidase gene under the control of the gC promoter-regulatory region. Each of these viruses had the same DNA sequences from the start of gC transcription upstream to -114 but had variable segments of the downstream 140-base-pair sequence that is between the start of gC transcription and translation. Analysis of beta-galactosidase expression and mRNA synthesis from these viruses demonstrated the importance of DNA sequences from the start of gC transcription downstream to +38 for optimal expression from the gC promoter.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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