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. 1989;67(3):317–325.

Iodine deficiency disorders in Europe.

F Delange, H Bürgi
PMCID: PMC2491245  PMID: 2670299

Abstract

Recent data on iodine excretion in the urine of adults, adolescents and newborns and on the iodine content of breast milk indicate a high prevalence of iodine deficiency (moderate in many cases and severe in a few) in many European countries. These cases may manifest as subclinical hypothyroidism in neonates and as goitre in adolescents and adults. Lack of iodine causes not only goitre, but also mental deficiency, hearing loss and other neurological impairments, and short stature due to thyroid insufficiency during fetal development and childhood. Although iodinated salt is available theoretically in most countries where it is needed, its quality and share of the market are often unsatisfactory. In many countries where only household salt is iodinated the iodine content has been set too low owing to an overestimation of household salt consumption. Governments are therefore urged to pass legislation and provide means for efficient iodination of salt wherever this is necessary.

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Selected References

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  1. Beevers D. G., Hawthorne V. M., Padfield P. L. Salt and blood pressure in Scotland. Br Med J. 1980 Sep 6;281(6241):641–642. doi: 10.1136/bmj.281.6241.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clark A. J., Mossholder S. Sodium and potassium intake measurements: dietary methodology problems. Am J Clin Nutr. 1986 Mar;43(3):470–476. doi: 10.1093/ajcn/43.3.470. [DOI] [PubMed] [Google Scholar]
  3. Costa A., De Filippis V., Bacolla A., Valerio De Carli J. Insufficiency of goiter prophylaxis by means of the iodinated salt actually available and under a voluntary basis. J Endocrinol Invest. 1986 Dec;9(6):529–529. doi: 10.1007/BF03346981. [DOI] [PubMed] [Google Scholar]
  4. Dauncey M. J., Widdowson E. M. Urinary excretion of calcium, magnesium, sodium, and potassium in hard and soft water areas. Lancet. 1972 Apr 1;1(7753):711–714. doi: 10.1016/s0140-6736(72)90230-9. [DOI] [PubMed] [Google Scholar]
  5. Delange F., Heidemann P., Bourdoux P., Larsson A., Vigneri R., Klett M., Beckers C., Stubbe P. Regional variations of iodine nutrition and thyroid function during the neonatal period in Europe. Biol Neonate. 1986;49(6):322–330. doi: 10.1159/000242547. [DOI] [PubMed] [Google Scholar]
  6. Etling N., Gehin-Fouque F. Iodinated compounds and thyroxine binding to albumin in human breast milk. Pediatr Res. 1984 Sep;18(9):901–903. doi: 10.1203/00006450-198409000-00020. [DOI] [PubMed] [Google Scholar]
  7. Evered D. C., Ormston B. J., Smith P. A., Hall R., Bird T. Grades of hypothyroidism. Br Med J. 1973 Mar 17;1(5854):657–662. doi: 10.1136/bmj.1.5854.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fenzi G. F., Bartalena L., Lombardi A., Chiovato L., Macchia E., Giani C., Pinchera A. Thyroid autoimmunity and endemic goiter. Endocrinol Exp. 1986 Mar;20(1):49–56. [PubMed] [Google Scholar]
  9. Frey H. Iodine status in Scandinavia. Acta Pharmacol Toxicol (Copenh) 1986;59 (Suppl 7):111–115. doi: 10.1111/j.1600-0773.1986.tb02719.x. [DOI] [PubMed] [Google Scholar]
  10. Gutekunst R., Smolarek H., Hasenpusch U., Stubbe P., Friedrich H. J., Wood W. G., Scriba P. C. Goitre epidemiology: thyroid volume, iodine excretion, thyroglobulin and thyrotropin in Germany and Sweden. Acta Endocrinol (Copenh) 1986 Aug;112(4):494–501. doi: 10.1530/acta.0.1120494. [DOI] [PubMed] [Google Scholar]
  11. Haas V., Marley M., Green A., Date J., Blichert-Toft M., Mogensen E. F. Urinary iodine excretion in a geographically stratified Danish population sample not affected by iodination programmes. A change towards higher values. Acta Endocrinol (Copenh) 1988 Sep;119(1):125–131. doi: 10.1530/acta.0.1190125. [DOI] [PubMed] [Google Scholar]
  12. Hall R., Lazarus J. H. Changing iodine intake and the effect on thyroid disease. Br Med J (Clin Res Ed) 1987 Mar 21;294(6574):721–722. doi: 10.1136/bmj.294.6574.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hansen J. M., Skovsted L., Siersbaek-Nielsen K. Age dependent changes in iodine metabolism and thyroid function. Acta Endocrinol (Copenh) 1975 May;79(1):60–65. doi: 10.1530/acta.0.0790060. [DOI] [PubMed] [Google Scholar]
  14. James W. P., Ralph A., Sanchez-Castillo C. P. The dominance of salt in manufactured food in the sodium intake of affluent societies. Lancet. 1987 Feb 21;1(8530):426–429. doi: 10.1016/s0140-6736(87)90127-9. [DOI] [PubMed] [Google Scholar]
  15. Lamberg B. A. Endemic goitre in Finland and changes during 30 years of iodine prophylaxis. Endocrinol Exp. 1986 Mar;20(1):35–47. [PubMed] [Google Scholar]
  16. Lamberg B. A., Haikonen M., Mäkelä M., Jukkara A., Axelson E., Welin M. G. Further decrease in thyroidal uptake and disappearance of endemic goitre in children after 30 years of iodine prophylaxis in the east of Finland. Acta Endocrinol (Copenh) 1981 Oct;98(2):205–209. doi: 10.1530/acta.0.0980205. [DOI] [PubMed] [Google Scholar]
  17. Lumholtz I. B., Poulsen D. L., Siersbaek-Nielsen K., Friis T., Rogowski P., Kirkegaard C., Hansen J. M. Outcome of long-term antithyroid treatment of graves' disease in relation to iodine intake. Acta Endocrinol (Copenh) 1977 Mar;84(3):538–541. doi: 10.1530/acta.0.0840538. [DOI] [PubMed] [Google Scholar]
  18. Mornex R. Enquête sur la prévalence du goitre en France. Bull Acad Natl Med. 1987 Mar;171(3):301–306. [PubMed] [Google Scholar]
  19. Sanchez-Castillo C. P., Branch W. J., James W. P. A test of the validity of the lithium-marker technique for monitoring dietary sources of salt in man. Clin Sci (Lond) 1987 Jan;72(1):87–94. doi: 10.1042/cs0720087. [DOI] [PubMed] [Google Scholar]
  20. Sanchez-Castillo C. P., Seidell J., James W. P. The potential use of lithium as a marker for the assessment of the sources of dietary salt: cooking studies and physiological experiments in men. Clin Sci (Lond) 1987 Jan;72(1):81–86. doi: 10.1042/cs0720081. [DOI] [PubMed] [Google Scholar]
  21. Sanchez-Castillo C. P., Warrender S., Whitehead T. P., James W. P. An assessment of the sources of dietary salt in a British population. Clin Sci (Lond) 1987 Jan;72(1):95–102. doi: 10.1042/cs0720095. [DOI] [PubMed] [Google Scholar]
  22. Sava L., Delange F., Belfiore A., Purrello F., Vigneri R. Transient impairment of thyroid function in newborn from an area of endemic goiter. J Clin Endocrinol Metab. 1984 Jul;59(1):90–95. doi: 10.1210/jcem-59-1-90. [DOI] [PubMed] [Google Scholar]
  23. Varo P., Saari E., Paaso A., Koivistoinen P. Iodine in Finnish foods. Int J Vitam Nutr Res. 1982;52(1):80–89. [PubMed] [Google Scholar]
  24. Weber P., Manz F., Kersting M., Schöch G. Jodsalzverbrauch und Kochsalzumsatz. Dtsch Med Wochenschr. 1986 Dec 12;111(50):1916–1921. doi: 10.1055/s-2008-1068735. [DOI] [PubMed] [Google Scholar]
  25. Wenlock R. W., Buss D. H., Moxon R. E., Bunton N. G. Trace nutrients. 4. Iodine in British food. Br J Nutr. 1982 May;47(3):381–390. doi: 10.1079/bjn19820049. [DOI] [PubMed] [Google Scholar]
  26. Williams D. R., Bingham S. A. Sodium and potassium intakes in a representative population sample: estimation from 24 h urine collections known to be complete in a Cambridgeshire village. Br J Nutr. 1986 Jan;55(1):13–22. doi: 10.1079/bjn19860005. [DOI] [PubMed] [Google Scholar]
  27. van Rees-Wortelboer M. M., Schröder-van der Elst J. P., Lycklama A., van der Heide D. Jodium en krop in Nederland. Ned Tijdschr Geneeskd. 1987 Oct 10;131(41):1821–1824. [PubMed] [Google Scholar]

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