Abstract
Based on the information available, transmission of human immunodeficiency virus (HIV) can and does occur in health-care settings. No cases of such transmission have been reported from an infected health-care worker to a patient. Transmission of HIV from an infected patient to a health-care worker has been documented after parenteral or mucous-membrane exposure to blood. However, this risk is less than 1%, is limited to exposure to blood, and can be further minimized through adherence to routine infection control measures. Patient-to-patient transmission through invasive equipment or through HIV-infected blood, blood products, organs, tissues, or semen also occurs but can be prevented by proper sterilization of instruments and through donor-deferral, donor screening, and heat treatment of Factors VIII or IX to inactivate the HIV. In health-care settings, prevention of HIV transmission requires education of all health-care workers and ancillary staff, provision of necessary equipment, and strict adherence to general infection control practices.
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Selected References
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- Armstrong F. P., Miner J. C., Wolfe W. H. Investigation of a health care worker with symptomatic human immunodeficiency virus infection: an epidemiologic approach. Mil Med. 1987 Aug;152(8):414–418. [PubMed] [Google Scholar]
- Barnes D. M. Health workers and AIDS: questions persist. Science. 1988 Jul 8;241(4862):161–162. doi: 10.1126/science.3388028. [DOI] [PubMed] [Google Scholar]
- Bygbjerg I. C. AIDS in a Danish surgeon (Zaire, 1976) Lancet. 1983 Apr 23;1(8330):925–925. doi: 10.1016/s0140-6736(83)91348-x. [DOI] [PubMed] [Google Scholar]
- Castro K. G., Lifson A. R., White C. R., Bush T. J., Chamberland M. E., Lekatsas A. M., Jaffe H. W. Investigations of AIDS patients with no previously identified risk factors. JAMA. 1988 Mar 4;259(9):1338–1342. [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) Apparent transmission of human T-lymphotrophic virus type III/lymphadenopathy-associated virus from a child to a mother providing health care. MMWR Morb Mortal Wkly Rep. 1986 Feb 7;35(5):76–79. [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) Recommendations for prevention of HIV transmission in health-care settings. MMWR Suppl. 1987 Aug 21;36(2):1S–18S. [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) Transmission of HIV through bone transplantation: case report and public health recommendations. MMWR Morb Mortal Wkly Rep. 1988 Oct 7;37(39):597–599. [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) Update: acquired immunodeficiency syndrome and human immunodeficiency virus infection among health-care workers. MMWR Morb Mortal Wkly Rep. 1988 Apr 22;37(15):229-34, 239. [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) Update: evaluation of human T-lymphotropic virus type III/lymphadenopathy-associated virus infection in health-care personnel--United States. MMWR Morb Mortal Wkly Rep. 1985 Sep 27;34(38):575–578. [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) Update: human immunodeficiency virus infections in health-care workers exposed to blood of infected patients. MMWR Morb Mortal Wkly Rep. 1987 May 22;36(19):285–289. [PubMed] [Google Scholar]
- Clarke J. A. HIV transmission and skin grafts. Lancet. 1987 Apr 25;1(8539):983–983. doi: 10.1016/s0140-6736(87)90335-7. [DOI] [PubMed] [Google Scholar]
- Donovan B. HIV transmission to a blood donor. Lancet. 1988 Aug 20;2(8608):452–452. doi: 10.1016/s0140-6736(88)90440-0. [DOI] [PubMed] [Google Scholar]
- Flynn N. M., Pollet S. M., Van Horne J. R., Elvebakk R., Harper S. D., Carlson J. R. Absence of HIV antibody among dental professionals exposed to infected patients. West J Med. 1987 Apr;146(4):439–442. [PMC free article] [PubMed] [Google Scholar]
- Jörbeck H., Steinkeller E. Personal i ett sjukvårdsområde. 41 fall av smittotillbud med HIV-positivt blod. Lakartidningen. 1988 Sep 21;85(38):3044–3045. [PubMed] [Google Scholar]
- Kohlhof A., Flessenkämper S. Tenth case of HIV transmission after plasma donation. Lancet. 1988 Oct 22;2(8617):965–965. doi: 10.1016/s0140-6736(88)92634-7. [DOI] [PubMed] [Google Scholar]
- Lepage P., Van de Perre P. Nosocomial transmission of HIV in Africa: what tribute is paid to contaminated blood transfusions and medical injections? Infect Control Hosp Epidemiol. 1988 May;9(5):200–203. doi: 10.1086/645833. [DOI] [PubMed] [Google Scholar]
- Lima G., Traina C. Considerazioni su un caso di sindrome correlata alla AIDS (ARC/LAS) in una operatrice sanitaria. Minerva Med. 1988 Feb;79(2):141–143. [PubMed] [Google Scholar]
- Mann J. M., Francis H., Davachi F., Baudoux P., Quinn T. C., Nzilambi N., Bosenge N., Colebunders R. L., Piot P., Kabote N. Risk factors for human immunodeficiency virus seropositivity among children 1-24 months old in Kinshasa, Zaire. Lancet. 1986 Sep 20;2(8508):654–657. doi: 10.1016/s0140-6736(86)90167-4. [DOI] [PubMed] [Google Scholar]
- McEvoy M., Porter K., Mortimer P., Simmons N., Shanson D. Prospective study of clinical, laboratory, and ancillary staff with accidental exposures to blood or body fluids from patients infected with HIV. Br Med J (Clin Res Ed) 1987 Jun 20;294(6587):1595–1597. doi: 10.1136/bmj.294.6587.1595. [DOI] [PMC free article] [PubMed] [Google Scholar]
- N'Galy B., Ryder R. W., Bila K., Mwandagalirwa K., Colebunders R. L., Francis H., Mann J. M., Quinn T. C. Human immunodeficiency virus infection among employees in an African hospital. N Engl J Med. 1988 Oct 27;319(17):1123–1127. doi: 10.1056/NEJM198810273191704. [DOI] [PubMed] [Google Scholar]
- Neisson-Vernant C., Arfi S., Mathez D., Leibowitch J., Monplaisir N. Needlestick HIV seroconversion in a nurse. Lancet. 1986 Oct 4;2(8510):814–814. doi: 10.1016/s0140-6736(86)90338-7. [DOI] [PubMed] [Google Scholar]
- Oksenhendler E., Harzic M., Le Roux J. M., Rabian C., Clauvel J. P. HIV infection with seroconversion after a superficial needlestick injury to the finger. N Engl J Med. 1986 Aug 28;315(9):582–582. doi: 10.1056/NEJM198608283150912. [DOI] [PubMed] [Google Scholar]
- Ponce de León S., Sánchez-Mejorada G., Zaidi-Jacobson M. AIDS in a blood bank technician in Mexico City. Infect Control Hosp Epidemiol. 1988 Mar;9(3):101–102. [PubMed] [Google Scholar]
- Sacks J. J. AIDS in a surgeon. N Engl J Med. 1985 Oct 17;313(16):1017–1018. doi: 10.1056/NEJM198510173131610. [DOI] [PubMed] [Google Scholar]
- Stewart G. J., Tyler J. P., Cunningham A. L., Barr J. A., Driscoll G. L., Gold J., Lamont B. J. Transmission of human T-cell lymphotropic virus type III (HTLV-III) by artificial insemination by donor. Lancet. 1985 Sep 14;2(8455):581–585. doi: 10.1016/s0140-6736(85)90585-9. [DOI] [PubMed] [Google Scholar]
- Stricof R. L., Morse D. L. HTLV-III/LAV seroconversion following a deep intramuscular needlestick injury. N Engl J Med. 1986 Apr 24;314(17):1115–1115. doi: 10.1056/NEJM198604243141711. [DOI] [PubMed] [Google Scholar]
- Wallace M. R., Harrison W. O. HIV seroconversion with progressive disease in health care worker after needlestick injury. Lancet. 1988 Jun 25;1(8600):1454–1454. doi: 10.1016/s0140-6736(88)92258-1. [DOI] [PubMed] [Google Scholar]
- Weiss S. H., Saxinger W. C., Rechtman D., Grieco M. H., Nadler J., Holman S., Ginzburg H. M., Groopman J. E., Goedert J. J., Markham P. D. HTLV-III infection among health care workers. Association with needle-stick injuries. JAMA. 1985 Oct 18;254(15):2089–2093. [PubMed] [Google Scholar]
