Abstract
Experiments on fertile hens' eggs have shown that an excess of vitamin A has a highly specific effect on the migration of cranial neural crest cells in the early stages of chick embryogenesis. Migration is disrupted and retarded. This is consistent with the causal mechanism proposed by Poswillo for the Treacher Collins syndrome.
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- Di Virgilio G., Lavenda N., Worden J. L. Sequence of events in neural tube closure and the formation of neural crest in the chick embryo. Acta Anat (Basel) 1967;68(1):127–146. doi: 10.1159/000143022. [DOI] [PubMed] [Google Scholar]
- Morriss G. M. The ultrastructural effects of excess maternal vitamin A on the primitive streak stage rat embryo. J Embryol Exp Morphol. 1973 Aug;30(1):219–242. [PubMed] [Google Scholar]
- Poswillo D. The pathogenesis of the Treacher Collins syndrome (mandibulofacial dysostosis). Br J Oral Surg. 1975 Jul;13(1):1–26. doi: 10.1016/0007-117x(75)90019-0. [DOI] [PubMed] [Google Scholar]
- Pratt R. M., Larsen M. A., Johnston M. C. Migration of cranial neural crest cells in a cell-free hyaluronate-rich matrix. Dev Biol. 1975 Jun;44(2):298–305. doi: 10.1016/0012-1606(75)90400-5. [DOI] [PubMed] [Google Scholar]