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. 1990 Feb;64(2):936–940. doi: 10.1128/jvi.64.2.936-940.1990

A monoclonal antibody to human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization.

P A Broliden 1, K Ljunggren 1, J Hinkula 1, E Norrby 1, L Akerblom 1, B Wahren 1
PMCID: PMC249194  PMID: 2296090

Abstract

Monoclonal antibodies (MAbs) were raised against human immunodeficiency virus type 1 gp120. One MAb, P4/D10, was found to mediate highly efficient antibody-dependent cellular cytotoxicity and virus neutralization. The reactivity was located to a major neutralizing region (amino acids 304 to 323) on gp120. Five other MAbs with a similar epitopic reactivity did not show any antibody-dependent cellulan cytotoxicity activity but had a virus-neutralizing capacity.

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Selected References

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