Abstract
One hundred and eight adult patients undergoing appendicectomy (37 advanced appendicitis and 71 early appendicitis or normal appendices) were randomised into a trial comparing the effects of ampicillin (anti-aerobic) and metronidazole (anti-anaerobic) based regimes. Although there were less wound infections amongst those patients receiving metronidazole (14%) as compared to ampicillin (27%) this difference failed to reach statistical significance. However, ampicillin appears to be superior in shortening the length of postoperative fever, 3.0 compared to 3.5 d for those patients receiving metronidazole. There is some suggestion that this advantage is reversed amongst those patients with wound infections. Further study is required to clarify this point. Our study suggests further evidence of differing clinical action of these drugs in appendicectomy.
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Selected References
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- Magarey C. J., Chant A. D., Rickford C. R., Margarey J. R. Peritoneal drainage and systemic antibiotics after appendicectomy. A prospective trial. Lancet. 1971 Jul 24;2(7717):179–182. doi: 10.1016/s0140-6736(71)90894-4. [DOI] [PubMed] [Google Scholar]
- Pinto D. J., Sanderson P. J. Rational use of antibiotic therapy after appendicectomy. Br Med J. 1980 Feb 2;280(6210):275–277. doi: 10.1136/bmj.280.6210.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rickett J. W., Jackson B. T. Topical ampicillin in the appendicectomy wound: report of double-blind trial. Br Med J. 1969 Oct 25;4(5677):206–207. doi: 10.1136/bmj.4.5677.206. [DOI] [PMC free article] [PubMed] [Google Scholar]