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. 1990 Mar;64(3):1375–1377. doi: 10.1128/jvi.64.3.1375-1377.1990

Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.

J J Treanor 1, E L Tierney 1, S L Zebedee 1, R A Lamb 1, B R Murphy 1
PMCID: PMC249260  PMID: 2304147

Abstract

The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.

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Selected References

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