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. 2008 Aug;124(4):461–468. doi: 10.1111/j.1365-2567.2007.02797.x

Figure 7.

Figure 7

The Effect of T cell depletion on tumour growth inhibition by the combinatorial treatment of AdmIL-12 and PDT. The role of CD8+ or CD4+ T cells in mediating the antitumour response was determined using the experimental design as described in Materials and methods. Day 0 indicates the PDT-treated day. *, No statistical significance in AdIL-12 + PDT versus AdIL-12 + PDT + anti-CD4 groups (anova); †, no statistical significance in AdLacZ + PDT versus AdmIL-12 + PDT + anti-CD8 groups; **, these groups (AdmIL-12 + PDT versus AdmIL-12 + PDT + anti-CD8 groups) were statistically significant (P< 0·05). Filled circle (•), untreated control; filled triangle (▴), injection of AdLacZ alone; filled square (⋆), injection of AdmIL-12 alone; open triangle (△), injection of AdLacZ followed by PDT; open square (□), injection of AdmIL-12 followed by PDT; filled diamond (♦), AdmIL-12 and PDT and anti-CD4 ascites; open diamond (⋄), AdmIL-12 and PDT and anti-CD8 ascites.