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. 1990 May;64(5):2260–2264. doi: 10.1128/jvi.64.5.2260-2264.1990

Heterotypic protection induced by synthetic peptides corresponding to three serotypes of foot-and-mouth disease virus.

T R Doel 1, C Gale 1, C M Do Amaral 1, G Mulcahy 1, R Dimarchi 1
PMCID: PMC249387  PMID: 2157884

Abstract

Synthetic peptide vaccines of the general sequence Cys-Cys(200-213)-Pro-Pro-Ser-(141-158)-Pro-Cys-Gly, where the numbered residues refer to VP1 sequences of three different strains of foot-and-mouth disease virus, have been evaluated in cattle and guinea pigs. High levels of serotype-specific (homotypic) antiviral and antipeptide antibody were produced with each peptide. The A- and O-serotype peptides provided complete protection of guinea pigs against their respective virus challenges. The C-serotype peptide appeared to be less effective than the other peptides. In cross-protection studies (heterotypic) in guinea pigs, it was possible to protect A-serotype peptide-vaccinated animals against O-virus challenge and vice versa. Some heterotypic protection was also achieved with the C-serotype peptide. The heterotypic protection observed related more to the presence of cross-reactive antipeptide antibody than to neutralizing antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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