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Journal of Virology logoLink to Journal of Virology
. 1990 Jun;64(6):2907–2911. doi: 10.1128/jvi.64.6.2907-2911.1990

Transcriptional activation of the adenine phosphoribosyltransferase promoter by an upstream butyrate-induced Moloney murine sarcoma virus enhancer-promoter element.

D C Tang 1, M W Taylor 1
PMCID: PMC249474  PMID: 2159551

Abstract

It has been documented that the activity of a specific promoter can be occluded by the presence of another promoter element upstream. We present evidence for a phenomenon contradictory to that predicted by the promoter occlusion theory. Transcription from the hamster aprt (adenine phosphoribosyltransferase) promoter was augmented instead of repressed in transfected mouse L cells when an upstream Moloney murine sarcoma virus enhancer-promoter element was induced with butyrate. Without an adjacent Moloney murine sarcoma virus element, butyrate could not activate the aprt promoter.

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Selected References

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