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Journal of Virology logoLink to Journal of Virology
. 1990 Jun;64(6):3078–3081. doi: 10.1128/jvi.64.6.3078-3081.1990

Evidence suggesting that virulence maps to the P1 region of the coxsackievirus B4 genome.

A Ramsingh 1, A Hixson 1, B Duceman 1, J Slack 1
PMCID: PMC249496  PMID: 2159563

Abstract

A chimeric virus containing the P1 region of a virulent variant of coxsackievirus B4 and the P2 and P3 regions of a nonvirulent strain was constructed from cDNA clones. The chimeric virus induced pancreatitis with concurrent hypoglycemia similar to that observed in mice infected with the virulent variant.

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Selected References

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