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. 1990 Jun;64(6):3091–3092. doi: 10.1128/jvi.64.6.3091-3092.1990

Mechanism of antibody-mediated viral clearance in immunotherapy of respiratory syncytial virus infection of cotton rats.

G A Prince 1, V G Hemming 1, R L Horswood 1, P A Baron 1, B R Murphy 1, R M Chanock 1
PMCID: PMC249499  PMID: 2186179

Abstract

Antibody-mediated clearance of respiratory syncytial virus from cotton rat pulmonary tissues occurs in the absence of complement and in the absence of the Fc portion of the immunoglobulin G molecule, suggesting that complement-independent, cell-independent neutralization is the major mechanism of clearance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexandersen S., Larsen S., Cohn A., Uttenthal A., Race R. E., Aasted B., Hansen M., Bloom M. E. Passive transfer of antiviral antibodies restricts replication of Aleutian mink disease parvovirus in vivo. J Virol. 1989 Jan;63(1):9–17. doi: 10.1128/jvi.63.1.9-17.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Hemming V. G., Prince G. A., Horswood R. L., London W. J., Murphy B. R., Walsh E. E., Fischer G. W., Weisman L. E., Baron P. A., Chanock R. M. Studies of passive immunotherapy for infections of respiratory syncytial virus in the respiratory tract of a primate model. J Infect Dis. 1985 Nov;152(5):1083–1087. doi: 10.1093/infdis/152.5.1083. [DOI] [PubMed] [Google Scholar]
  3. Hemming V. G., Rodriguez W., Kim H. W., Brandt C. D., Parrott R. H., Burch B., Prince G. A., Baron P. A., Fink R. J., Reaman G. Intravenous immunoglobulin treatment of respiratory syncytial virus infections in infants and young children. Antimicrob Agents Chemother. 1987 Dec;31(12):1882–1886. doi: 10.1128/aac.31.12.1882. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Mandel B. Neutralization of animal viruses. Adv Virus Res. 1978;23:205–268. doi: 10.1016/S0065-3527(08)60101-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Prince G. A., Hemming V. G., Horswood R. L., Baron P. A., Chanock R. M. Effectiveness of topically administered neutralizing antibodies in experimental immunotherapy of respiratory syncytial virus infection in cotton rats. J Virol. 1987 Jun;61(6):1851–1854. doi: 10.1128/jvi.61.6.1851-1854.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Prince G. A., Hemming V. G., Horswood R. L., Chanock R. M. Immunoprophylaxis and immunotherapy of respiratory syncytial virus infection in the cotton rat. Virus Res. 1985 Oct;3(3):193–206. doi: 10.1016/0168-1702(85)90045-0. [DOI] [PubMed] [Google Scholar]
  7. Prince G. A., Jenson A. B., Horswood R. L., Camargo E., Chanock R. M. The pathogenesis of respiratory syncytial virus infection in cotton rats. Am J Pathol. 1978 Dec;93(3):771–791. [PMC free article] [PubMed] [Google Scholar]

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