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. 1972 Mar;48(557):133–137. doi: 10.1136/pgmj.48.557.133

The effect of methoxyflurane analgesia on renal function in burned patients: an investigation

S M Laird, Kathleen M R Chrystal
PMCID: PMC2495211  PMID: 5024150

Abstract

This paper reports an investigation into evidence of renal dysfunction following methoxyflurane analgesia for burns dressings.

Twelve patients were studied and small increases in serum uric acid were observed in all of them. This increase may have been dose-related.

Four patients had small but consistent increases in blood urea nitrogen and serum creatinine on the third post-dressing day.

No definite conclusions can be adduced and further research is needed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Crandell W. B., Pappas S. G., Macdonald A. Nephrotoxicity associated with methoxyflurane anesthesia. Anesthesiology. 1966 Sep-Oct;27(5):591–607. doi: 10.1097/00000542-196609000-00010. [DOI] [PubMed] [Google Scholar]
  2. EGER E. I., 2nd, BRANDSTATER B. SOLUBILITY OF METHOXYFLURANE IN RUBBER. Anesthesiology. 1963 Sep-Oct;24:679–683. doi: 10.1097/00000542-196309000-00018. [DOI] [PubMed] [Google Scholar]
  3. EGER E. I., 2nd UPTAKE OF METHOXYFLURANE IN MAN AT CONSTANT ALVEOLAR AND AT CONSTANT INSPIRED CONCENTRATION. Anesthesiology. 1964 May-Jun;25:284–290. doi: 10.1097/00000542-196405000-00004. [DOI] [PubMed] [Google Scholar]
  4. Elkington S. G., Goffinet J. A., Conn H. O. Renal and hepatic injury associated with methoxyflurane anesthesia. Ann Intern Med. 1968 Dec;69(6):1229–1236. doi: 10.7326/0003-4819-69-6-1229. [DOI] [PubMed] [Google Scholar]
  5. Kuzucu E. Y. Methoxyflurane, tetracycline, and renal failure. JAMA. 1970 Feb 16;211(7):1162–1164. [PubMed] [Google Scholar]
  6. Lapointe A., Bele-Binda N. Nephrotoxicite associee au methoxyflurane. Can Anaesth Soc J. 1970 Mar;17(2):145–156. doi: 10.1007/BF03004665. [DOI] [PubMed] [Google Scholar]
  7. Lebowitz M. H. Nephrogenic diabetes insipidus following methoxyflurane anesthesia. A report of two cases. Anesth Analg. 1969 Mar-Apr;48(2):233–236. [PubMed] [Google Scholar]
  8. Mazze R. I., Shue G. L., Jackson S. H. Renal dysfunction associated with methoxyflurane anesthesia. A randomized, prospective clinical evaluation. JAMA. 1971 Apr 12;216(2):278–288. [PubMed] [Google Scholar]
  9. Mignault G., Labrecque B., Hamel S. Méthoxyflurane et néphrotoxicité: étude de la fonction rénale de 22 malades anesthesiés au méthoxyflurane. Can Anaesth Soc J. 1970 Jul;17(4):331–340. doi: 10.1007/BF03004696. [DOI] [PubMed] [Google Scholar]
  10. Packer K. J., Titel J. H. Methoxyflurane analgesia for burns dressings: experience with the analgizer. Br J Anaesth. 1969 Dec;41(12):1080–1085. doi: 10.1093/bja/41.12.1080. [DOI] [PubMed] [Google Scholar]
  11. Panner B. J., Freeman R. B., Roth-Moyo L. A., Markowitch W., Jr Toxicity following methoxyflurane anesthesia. I. Clinical and pathological observations in two fatal cases. JAMA. 1970 Oct 5;214(1):86–90. doi: 10.1001/jama.214.1.86. [DOI] [PubMed] [Google Scholar]
  12. Snyder R. D., McCall D. M., Hayes M. A. Functional defect in postoperative polyuric renal failure. Surg Forum. 1966;17:19–21. [PubMed] [Google Scholar]
  13. Taves D. R., Fry B. W., Freeman R. B., Gillies A. J. Toxicity following methoxyflurane anesthesia. II. Fluoride concentrations in nephrotoxicity. JAMA. 1970 Oct 5;214(1):91–95. [PubMed] [Google Scholar]
  14. Taves D. R., Gillies A. J., Freeman R. B., Fry B. W. Toxicity following methoxyflurane anesthesia. 3. Hemodialysis of metabolites. JAMA. 1970 Oct 5;214(1):96–97. [PubMed] [Google Scholar]
  15. YU T. F., GUTMAN A. B. Paradoxical retention of uric acid by uricosuric drugs in low dosage. Proc Soc Exp Biol Med. 1955 Nov;90(2):542–547. doi: 10.3181/00379727-90-22094. [DOI] [PubMed] [Google Scholar]

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