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. 1972 Jul;48(561):399–404. doi: 10.1136/pgmj.48.561.399

Hypertension following cadaveric renal transplantation

G A Coles, G R Jones, D L Crosby, J H Jones, S McVeigh
PMCID: PMC2495253  PMID: 4560783

Abstract

The incidence and aetiology of hypertension following cadaveric-donor renal transplantation have been investigated in twenty-four patients. Initially, the diastolic blood pressure was persistently above 100 mmHg in 52% of the patients. By 1 month after renal transplantation the incidence had fallen to 17% but it then increased rapidly, so that by 5 months 83% had hypertension.

Changes in blood pressure correlated poorly with changes in the dose of prednisone, extracellular fluid volume, exchangeable sodium, creatinine clearance and haemoglobin.

The recipient's original diseased kidneys were removed after transplantation in seven patients. The blood pressure fell to normal levels in three, remained unchanged in two and became easier to control with antihypertensive drugs in the other two patients. Measurements of plasma renin concentration were of no value in predicting the response to recipient nephrectomy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbrecht P. H., Vander A. J., Turcotte J. G. Effects of saline loading on the renin, erythropoietin, and blood pressure responses to canine renal allotransplantation. Circ Res. 1969 Aug;25(2):99–105. doi: 10.1161/01.res.25.2.99. [DOI] [PubMed] [Google Scholar]
  2. BUNIM J. J., BLACK R. L., LUTWAK L., PETERSON R. E., WHEDON G. D. Studies on dexamethasone, a new synthetic steroid, in rheurheumatoid arthritis: a preliminary report; adrenal cortical, metabolic and early clinical effects. Arthritis Rheum. 1958 Aug;1(4):313–331. doi: 10.1002/art.1780010404. [DOI] [PubMed] [Google Scholar]
  3. Blaufox M. D., Birbari A. E., Hickler R. B., Merrill J. P. Peripheral plasma renin activity in renal-homotransplant recipients. N Engl J Med. 1966 Nov 24;275(21):1165–1168. doi: 10.1056/NEJM196611242752105. [DOI] [PubMed] [Google Scholar]
  4. Blumberg A., Nelp W. B., Hegstrom R. M., Scribner B. H. Extracellular volume in patients with chronic renal disease treated for hypertension by sodium restriction. Lancet. 1967 Jul 8;2(7506):69–73. doi: 10.1016/s0140-6736(67)92061-2. [DOI] [PubMed] [Google Scholar]
  5. Branch R. A., Coles G. A., Crosby D. L., Jones J. H., Sussman M., Thomas W. J. Integrated regional haemodialysis and renal transplantation centre. Br Med J. 1970 Jan 31;1(5691):291–294. doi: 10.1136/bmj.1.5691.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brown J. J., Curtis J. R., Lever A. F., Robertson J. I., De Wardener H. E., Wing A. J. Plasma renin concentration and the control of blood pressure in patients on maintenance haemodialysis. Nephron. 1969;6(3):329–349. doi: 10.1159/000179737. [DOI] [PubMed] [Google Scholar]
  7. Brown J. J., Davies D. L., Lever A. F., Robertson J. I., Tree M. The estimation of renin in human plasma. Biochem J. 1964 Dec;93(3):594–600. doi: 10.1042/bj0930594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ducrot H., Jungers P., Funck-Brentano J. L., Perrin D., Crosnier J., Hamburger J. La correction de l'hypertension artérielle par la transplantation rénale chez l'homme. Pathol Biol. 1965 Nov;13(21):1070–1076. [PubMed] [Google Scholar]
  9. Gunnells C. J., Jr, Stickel D. L., Robinson R. R. Episodic hypertension associated with positive renin assays after renal transplantation. N Engl J Med. 1966 Mar 10;274(10):543–547. doi: 10.1056/NEJM196603102741004. [DOI] [PubMed] [Google Scholar]
  10. HAMBURGER J., CROSNIER J., DORMONT J. EXPERIENCE WITH 45 RENAL HOMOTRANSPLANTATIONS IN MAN. Lancet. 1965 May 8;1(7393):985–992. doi: 10.1016/s0140-6736(65)91218-3. [DOI] [PubMed] [Google Scholar]
  11. Hume D. M. Renal homotransplantation in man. Annu Rev Med. 1967;18:229–268. doi: 10.1146/annurev.me.18.020167.001305. [DOI] [PubMed] [Google Scholar]
  12. NICHOLSON J. P., ZILVA J. F. Estimation of extracellular fluid volume using radiobromine. Clin Sci. 1960 Aug;19:391–398. [PubMed] [Google Scholar]
  13. OWEN J. A., IGGO B., SCANDRETT F. J., STEWART C. P. The determination of creatinine in plasma or serum, and in urine; a critical examination. Biochem J. 1954 Nov;58(3):426–437. doi: 10.1042/bj0580426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. PEARSON R. S., BAYLIS J. H., SMELLIE H. C. Treatment of chronic asthma with prednisolone and the newer steroids. Br Med J. 1961 Feb 4;1(5222):315–319. doi: 10.1136/bmj.1.5222.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Papadimitriou M., Chisholm G. D., Shackman R. Hypertension in patients on regular haemodialysis and after renal allotransplantation. Lancet. 1969 May 3;1(7601):902–904. doi: 10.1016/s0140-6736(69)92542-2. [DOI] [PubMed] [Google Scholar]
  16. REES H. A., WILLIAMS D. A. Long-term steroid therapy in chronic intractable asthma. A study of 317 adult asthmatics on continuous steroid therapy for an average period of 2 1/2 years. Br Med J. 1962 Jun 9;1(5292):1575–1579. doi: 10.1136/bmj.1.5292.1575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SIMSO L. A., TELANDER R. L., HITCHCOCK C. R. HYPERTENSION FOLLOWING RENAL AUTOGRAFTING IN THE KENYA BABOON. Surg Forum. 1963;14:170–171. [PubMed] [Google Scholar]
  18. STARZL T. E., MARCHIORO T. L., PORTER K. A., MOORE C. A., RIFKIND D., WADDELL W. R. RENAL HOMOTRANSPLANTATION; LATE FUNCTION AND COMPLICATIONS. Ann Intern Med. 1964 Sep;61:470–497. doi: 10.7326/0003-4819-61-3-470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Swales J. D., Evans D. B. Erythraemia in renal transplantation. Br Med J. 1969 Apr 12;2(5649):80–83. doi: 10.1136/bmj.2.5649.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Swales J. D. Sodium metabolism in relation to changing blood pressure levels in human renal transplantation. Am J Med Sci. 1967 May;253(5):531–538. [PubMed] [Google Scholar]
  21. Verniory A., Cuykens J. J., Lotteau B., Toussaint C. Dosage de la rénine plasmatique dans l'hypertension rénale (rénovasculaire ou parenchymateuse). Effets de la reconstruction vasculaire, de la néphrectomie et de la greffe rénale. J Urol Nephrol (Paris) 1967 Apr-May;73(4):276–285. [PubMed] [Google Scholar]
  22. West T. H., Turcotte J. G., Vander A. Plasma renin activity, sodium balance, and hypertension in a group of renal transplant recipients. J Lab Clin Med. 1969 Apr;73(4):564–573. [PubMed] [Google Scholar]

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