Abstract
A patient is described in whom malignant hypertension led to oliguric renal failure. A course of trimethoprim and sulphamethoxazole (co-trimoxazole) was prescribed for an intercurrent urinary tract infection and appeared to precipitate a megaloblastic anaemia which responded satisfactorily to folic acid.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allison M. E., Kennedy A. C., McGeachie J., McDonald G. A. Sulphamethoxazole-trimethoprim therapy in urinary tract infection with reference to its haematological effects. Scott Med J. 1969 Oct;14(10):355–360. doi: 10.1177/003693306901401004. [DOI] [PubMed] [Google Scholar]
- CHANARIN I., DACIE J. V., MOLLIN D. L. Folic-acid deficiency in haemolytic anaemia. Br J Haematol. 1959 Jul;5:245–256. doi: 10.1111/j.1365-2141.1959.tb04032.x. [DOI] [PubMed] [Google Scholar]
- Clarkson A. R., Lawrence J. R., Meadows R., Seymour A. E. The haemolytic uraemic syndrome in adults. Q J Med. 1970 Apr;39(154):227–244. [PubMed] [Google Scholar]
- Hulme B., Reeves D. S. Leucopenia associated with trimethoprim-sulphamethoxazole after renal transplantation. Br Med J. 1971 Sep 11;3(5775):610–612. doi: 10.1136/bmj.3.5775.610. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kahn S. B., Fein S. A., Brodsky I. Effects of trimethoprim on folate metabolism in man. Clin Pharmacol Ther. 1968 Sep-Oct;9(5):550–560. doi: 10.1002/cpt196895550. [DOI] [PubMed] [Google Scholar]
- Sevitt L. H., Hoffbrand A. V. Serum folate and vitamin B12 levels in acute and chronic renal disease. Effect of peritoneal dialysis. Br Med J. 1969 Apr 5;2(5648):18–21. doi: 10.1136/bmj.2.5648.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
