Abstract
In a series of forty-one episodes of diabetic coma or pre-coma, three patients had plasma potassium values of less than 3.0 mEq/l. All three had been taking thiazide diuretics with only one receiving oral potassium supplements. None was previously known to be diabetic, representing 18% of the new diabetics in the series. The mean plasma potassium for the other new diabetics was 4·7 ± 0·2 mEq/l. These findings emphasize that adequate potassium supplements should be given with thiazide diuretics to diabetic subjects and to those with an increased risk of developing the disease.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abramson E., Arky R. Diabetic acidosis with initial hypokalemia. Therapeutic implications. JAMA. 1966 May 2;196(5):401–403. [PubMed] [Google Scholar]
- Andersen O. O., Persson I. Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid. Br Med J. 1968 Jun 29;2(5608):798–801. doi: 10.1136/bmj.2.5608.798. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beigelman P. M. Severe diabetic ketoacidosis (diabetic "coma"). 482 episodes in 257 patients; experience of three years. Diabetes. 1971 Jul;20(7):490–500. doi: 10.2337/diab.20.7.490. [DOI] [PubMed] [Google Scholar]
- Bojanowicz K., Zubowski A. Beziehungen zwischen Kalium- und Kohlenhydratstoffwechselstörungen bei Diabetes Mellitus. Diabetologia. 1967 Dec;3(6):500–505. doi: 10.1007/BF01213568. [DOI] [PubMed] [Google Scholar]
- Breckenridge A., Welborn T. A., Dollery C. T., Fraser R. Glucose tolerance in hypertensive patients on long-term diuretic therapy. Lancet. 1967 Jan 14;1(7481):61–64. doi: 10.1016/s0140-6736(67)92470-1. [DOI] [PubMed] [Google Scholar]
- COHEN A. S., VANCE V. K., RUNYAN J. W., Jr, HURWITZ D. Diabetic acidosis: an evaluation of the cause, course and therapy of 73 cases. Ann Intern Med. 1960 Jan;52:55–86. doi: 10.7326/0003-4819-52-1-55. [DOI] [PubMed] [Google Scholar]
- Cryer P. E., Daughaday W. H. Diabetic ketosis: elevated serum glutamic-oxaloacetic transaminase (SGOT) and other findings determined by multi-channel chemical analysis. Diabetes. 1969 Nov;18(11):781–785. doi: 10.2337/diab.18.11.781. [DOI] [PubMed] [Google Scholar]
- Dobrzański T. Badania nad tzw. cukrzyca chlortalidonowa u psychicznie chorych. Endokrynol Pol. 1969 Sep-Oct;20(5):391–398. [PubMed] [Google Scholar]
- GOLDNER M. G., ZAROWITZ H., AKGUN S. Hyperglycemia and glycosuria due to thiazide derivatives administered in diabetes mellitus. N Engl J Med. 1960 Feb 25;262:403–405. doi: 10.1056/NEJM196002252620807. [DOI] [PubMed] [Google Scholar]
- Healy J. J., McKenna T. J., Canning B. S., Brien T. G., Duffy G. J., Muldowney F. P. Body composition changes in hypertensive subjects on long-term oral diuretic therapy. Br Med J. 1970 Mar 21;1(5698):716–719. doi: 10.1136/bmj.1.5698.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kiraly J. F., Becker C. E., Williams H. E. Diabetic ketoacidosis. A review of cases at a university medical center. Calif Med. 1970 Apr;112(4):1–9. [PMC free article] [PubMed] [Google Scholar]
- MORET B. ZUR DIABETOGENEN WIRKUNG DER SALURETIKA. Dtsch Med Wochenschr. 1965 Jun 18;90:1136–1139. doi: 10.1055/s-0028-1111481. [DOI] [PubMed] [Google Scholar]
- NICOLE J. C., PULVER W. [Hyperglycemic effect by means of salidiuretics in diabetes mellitus]. Helv Med Acta. 1962 Dec;29:556–562. [PubMed] [Google Scholar]
- Portier A., Chatelain P., Caillard B., Irr P., Portier C. Coma hyperglycémique sans cétose, avec déshydratation, déplétion chloro-sodique et potassique, après traitement par salidiurétiques, chez des malades non diabétiques. Sem Hop. 1968 Nov 26;44(49):3017–3025. [PubMed] [Google Scholar]
- RAPOPORT M. I., HURD H. F. THIAZIDE-INDUCED GLUCOSE INTOLERANCE TREATED WITH POTASSIUM. Arch Intern Med. 1964 Mar;113:405–408. doi: 10.1001/archinte.1964.00280090091014. [DOI] [PubMed] [Google Scholar]
- SAGILD U., ANDERSEN V., ANDREASEN P. B. Glucose tolerance and insulin responsiveness in experimental potassium depletion. Acta Med Scand. 1961 Mar;169:243–251. doi: 10.1111/j.0954-6820.1961.tb07829.x. [DOI] [PubMed] [Google Scholar]
- Telfer N. Exchangeable potassium in diabetics. Metabolism. 1966 Jun;15(6):502–509. doi: 10.1016/0026-0495(66)90110-7. [DOI] [PubMed] [Google Scholar]