Abstract
The chemical structures and serological specificities of polysaccharides isolated from four species of dermatophytes, Microsporum praecox, Trichophyton ferrugineum, T. sabouraudii, and T. tonsurans, were investigated. Each of these species yielded a mixture of crude polysaccharides which could be separated into three water-soluble, neutral polysaccharides free of nitrogen. These were grouped as galactomannan I, galactomannan II, and glucan. The galactomannans I were quite similar in chemical structure. When measured by complement fixation, their serological cross-reactivities were similar with rabbit antisera to each of these species except T. sabouraudii. The differences in their relative reactivities with this antiserum could be correlated with differences in structure and specificity of this antiserum for galactofuranose end groups. The galactomannans II differed both in chemical structure and in their serological reactivities with antisera to each of these species. The galactomannan II from T. ferrugineum differed most in chemical structure and was the least reactive serologically. The glucans also differed in both structure and serological reactivities.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Grappel S. F., Blank F., Bishop C. T. Immunological studies on dermatophytes. 3. Further analyses of the reactivities of neutral polysaccharides with rabbit antisera to Microsporum quinckeanum, Trichophyton schoenleinii, Trichophyton rubrum, Trichophyton interdigitale, and Trichophyton granulosum. J Bacteriol. 1968 Jul;96(1):70–75. doi: 10.1128/jb.96.1.70-75.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grappel S. F., Blank F., Bishop C. T. Immunological studies on dermatophytes. I. Serological reactivities of neutral polysaccharides with rabbit antiserum to Microsporum quinckeanum. J Bacteriol. 1967 Mar;93(3):1001–1008. doi: 10.1128/jb.93.3.1001-1008.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grappel S. F., Blank F., Bishop C. T. Immunological studies on dermatophytes. II. J Bacteriol. 1968 Apr;95(4):1238–1242. doi: 10.1128/jb.95.4.1238-1242.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]