Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1973 Mar;49(569):211–213. doi: 10.1136/pgmj.49.569.211

A neonatal complication of maternal leukaemia treated with 6-mercaptopurine

J B McConnell, R Bhoola
PMCID: PMC2495383  PMID: 4528388

Abstract

A 24-year-old African mother, who had received 6-mercaptopurine for acute leukaemia from before conception and throughout her pregnancy is described. The child, born prematurely, was anaemic at birth, with many features of a micro-angiopathic haemolytic anaemia. It is suggested that the mother's disease or treatment was involved in the aetiology of this anaemia.

Full text

PDF
211

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FRENKEL E. P., MEYERS M. C. Acute leukemia and pregnancy. Ann Intern Med. 1960 Oct;53:656–671. doi: 10.7326/0003-4819-53-4-656. [DOI] [PubMed] [Google Scholar]
  2. Hoover B. A., 2nd, Schumacher H. R. Acute leukemia in pregnancy. Am J Obstet Gynecol. 1966 Oct 1;96(3):316–320. doi: 10.1016/0002-9378(66)90232-8. [DOI] [PubMed] [Google Scholar]
  3. MERSKEY C., RIGAL W. Pregnancy in acute leukaemia treated with 6-mercaptopurine. Lancet. 1956 Dec 15;271(6955):1268–1269. doi: 10.1016/s0140-6736(56)90039-3. [DOI] [PubMed] [Google Scholar]
  4. RIGBY P. G., HANSON T. A., SMITH R. S. PASSAGE OF LEUKEMIC CELLS ACROSS THE PLACENTA. N Engl J Med. 1964 Jul 16;271:124–127. doi: 10.1056/NEJM196407162710304. [DOI] [PubMed] [Google Scholar]
  5. ROTHBERG H., CONRAD M. E., COWLEY R. G. Acute granulocytic leukemia in pregnancy: report of four cases, with apparent acceleration by prednisone in one. Am J Med Sci. 1959 Feb;237(2):194–204. doi: 10.1097/00000441-195902000-00007. [DOI] [PubMed] [Google Scholar]
  6. THIERSCH J. B. The effect of 6-mercaptopurine on the rat fetus and on reproduction of the rat. Ann N Y Acad Sci. 1954 Dec 6;60(2):220–227. doi: 10.1111/j.1749-6632.1954.tb40012.x. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES