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. 1972 Oct;48(564):594–598. doi: 10.1136/pgmj.48.564.594

The treatment of chronic pain with psychotropic drugs

H Merskey, R A Hester
PMCID: PMC2495400  PMID: 4404064

Abstract

The treatment is described of thirty patients with chronic nervous system lesion causing intractable pain. Moderately good relief of pain was obtained with a combination of phenothiazines (especially pericyazine), antidepressant drugs and antihistamines.

The theoretical implications of this are discussed and it is suggested that the drugs in question act partly by virtue of an effect on the multisynaptic neuronal systems whose activities are related to the experience of pain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLOOMFIELD S., SIMARD-SAVOIE S., BERNIER J., TETREAULT L. COMPARATIVE ANALGESIC ACTIVITY OF LEVOMEPROMAZINE AND MORPHINE IN PATIENTS WITH CHRONIC PAIN. Can Med Assoc J. 1964 May 16;90:1156–1159. [PMC free article] [PubMed] [Google Scholar]
  2. BROOK C. P. PSYCHIATRIC UNITS IN GENERAL HOSPITALS. Lancet. 1964 Nov 14;2(7368):1067–1068. doi: 10.1016/s0140-6736(64)91026-8. [DOI] [PubMed] [Google Scholar]
  3. De Alarcon R., Carney M. W. Severe depressive mood changes following slow-release intramuscular fluphenazine injection. Br Med J. 1969 Sep 6;3(5670):564–567. doi: 10.1136/bmj.3.5670.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. EGBERT L. D., BATTIT G. E., WELCH C. E., BARTLETT M. K. REDUCTION OF POSTOPERATIVE PAIN BY ENCOURAGEMENT AND INSTRUCTION OF PATIENTS. A STUDY OF DOCTOR-PATIENT RAPPORT. N Engl J Med. 1964 Apr 16;270:825–827. doi: 10.1056/NEJM196404162701606. [DOI] [PubMed] [Google Scholar]
  5. LANCE J. W., CURRAN D. A. TREATMENT OF CHRONIC TENSION HEADACHE. Lancet. 1964 Jun 6;1(7345):1236–1239. doi: 10.1016/s0140-6736(64)91866-5. [DOI] [PubMed] [Google Scholar]
  6. LASAGNA L., DEKORNFELD T. J. Methotrimeprazine: a new phenothiazine derivative with analgesic properties. JAMA. 1961 Dec 2;178:887–890. doi: 10.1001/jama.1961.03040480017004. [DOI] [PubMed] [Google Scholar]
  7. Lascelles R. G. Atypical facial pain and depression. Br J Psychiatry. 1966 Jul;112(488):651–659. doi: 10.1192/bjp.112.488.651. [DOI] [PubMed] [Google Scholar]
  8. Merskey H. The characteristics of persistent pain in psychological illness. J Psychosom Res. 1965 Dec;9(3):291–298. doi: 10.1016/0022-3999(65)90054-1. [DOI] [PubMed] [Google Scholar]
  9. PANACCIO V. Trimeprazine, a new phenothiazine derivative for treatment of pruritic dermatoses. Can Med Assoc J. 1959 Jun 1;80(11):885–886. [PMC free article] [PubMed] [Google Scholar]
  10. PARADIS B. Analgesic and anaesthetic properties of levomepromazine (Nozinan) (R.P. 704). Can Anaesth Soc J. 1962 Mar;9:153–160. doi: 10.1007/BF03021257. [DOI] [PubMed] [Google Scholar]
  11. ROSNER S. The potentiating effect of diphenhydramine hydrochloride (benadryl). J Nerv Ment Dis. 1957 Apr-Jun;125(2):229–231. doi: 10.1097/00005053-195704000-00009. [DOI] [PubMed] [Google Scholar]
  12. SAUNDERS C. The treatment of intractable pain in terminal cancer. Proc R Soc Med. 1963 Mar;56:195–197. doi: 10.1177/003591576305600322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SIGWALD J., BOUTTIER D., CAILLE F. [The treatment of zona and of its associated pains. Study of the results obtained with levomepromazine]. Therapie. 1959;14:818–824. [PubMed] [Google Scholar]
  14. Saunders C., Winner A. Analgesics in terminal disease. Br Med J. 1971 Jul 24;3(5768):245–245. doi: 10.1136/bmj.3.5768.245. [DOI] [PMC free article] [PubMed] [Google Scholar]

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