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. 1990 Jul;64(7):3234–3239. doi: 10.1128/jvi.64.7.3234-3239.1990

A novel T-cell protein which recognizes a palindromic sequence in the negative regulatory element of the human immunodeficiency virus long terminal repeat.

K Orchard 1, N Perkins 1, C Chapman 1, J Harris 1, V Emery 1, G Goodwin 1, D Latchman 1, M Collins 1
PMCID: PMC249541  PMID: 2352322

Abstract

Two major protein-binding sites within the negative regulatory element of the human immunodeficiency virus type 1 long terminal repeat have been identified. One (site B) contained a palindromic sequence with homology to steroid/thyroid hormone response elements but was distinct from previously described binding sites of this class. A novel T-cell protein recognized the palindromic sequence within site B and also bound estrogen- or thyroid hormone-response elements with lower affinity. A 7-base-pair mutation in the site B palindrome, which destroyed protein binding, resulted in increased expression from the human immunodeficiency virus type 1 long terminal repeat in T cells.

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Selected References

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