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. 1974 Jan;50(579):33–36. doi: 10.1136/pgmj.50.579.33

Periodic synoviosis (intermittent hydrarthrosis) with observations and studies on a patient

Hobart A Reimann
PMCID: PMC2495507  PMID: 4464498

Abstract

More than 200 instances of periodic synoviosis have been recorded. It is related to periodic oedema (hereditary angioedema). Various autonomic disturbances accompany episodes. Confusion with rheumatoid arthritis persists. Theoretically an inherent rhythm or feedback mechanism operates as the cause.

The disorder in several observed patients has persisted for decades, worsened or abated. In one instance, contraceptive medication failed to suppress episodes in contrast to the effect of pregnancy in some patients. E-aminocaproic acid disturbed the rhythm and gave mild relief. A few episodes were suppressed after two surgical operations. The inhibitor of Cl esterase in one patient lacked as much as it does in periodic oedema.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Champion R. H., Lachmann P. J. Hereditary angio-oedema treated with E-aminocaproic acid. Br J Dermatol. 1969 Oct;81(10):763–765. doi: 10.1111/j.1365-2133.1969.tb15938.x. [DOI] [PubMed] [Google Scholar]
  2. DONALDSON V. H., EVANS R. R. A BIOCHEMICAL ABNORMALITY IN HEREDIATRY ANGIONEUROTIC EDEMA: ABSENCE OF SERUM INHIBITOR OF C' 1-ESTERASE. Am J Med. 1963 Jul;35:37–44. doi: 10.1016/0002-9343(63)90162-1. [DOI] [PubMed] [Google Scholar]
  3. Donaldson V. H. Serum inhibitor of C'1-esterase in health and disease. J Lab Clin Med. 1966 Sep;68(3):369–382. [PubMed] [Google Scholar]
  4. Frank M. M., Sergent J. S., Kane M. A., Alling D. W. Epsilon aminocaproic acid therapy of hereditary angioneurotic edema. A double-blind study. N Engl J Med. 1972 Apr 13;286(15):808–812. doi: 10.1056/NEJM197204132861503. [DOI] [PubMed] [Google Scholar]
  5. GHORMLEY R. K., WEINER A. D. Periodic benign synovitis; idiopathic intermittent hydrarthrosis. J Bone Joint Surg Am. 1956 Oct;38-A(5):1039–1055. [PubMed] [Google Scholar]
  6. Lundh B., Laurell A. B., Wetterqvist H., White T., Granerus G. A case of hereditary angioneurotic oedema, successfully treated with epsilon-aminocaproic acid. Studies on C'1 esterase inhibitor, C'1 activation, plasminogen level and histamine metabolism. Clin Exp Immunol. 1968 Sep;3(7):733–745. [PMC free article] [PubMed] [Google Scholar]
  7. Morley A. Periodic diseases, physiological rhythms and feedback control--a hypothesis. Australas Ann Med. 1970 Aug;19(3):244–249. doi: 10.1111/imj.1970.19.3.244. [DOI] [PubMed] [Google Scholar]
  8. Pickering R. J., Good R. A., Kelly J. R., Gewurz H. Replacement therapy in hereditary angioedema. Successful treatment of two patients with fresh frozen plasma. Lancet. 1969 Feb 15;1(7590):326–330. doi: 10.1016/s0140-6736(69)91295-1. [DOI] [PubMed] [Google Scholar]
  9. REIMANN H. A., ANGELIDES A. P. Periodic arthralgia in twenty-three members of five generations of a family. J Am Med Assoc. 1951 Jun 23;146(8):713–716. doi: 10.1001/jama.1951.03670080021006. [DOI] [PubMed] [Google Scholar]
  10. RUSTAD H., MYHRE E. Surgery during anticoagulant treatment. The risk of increased bleeding in patients on oral anticoagulant treatment. Acta Med Scand. 1963 Jan;173:115–119. [PubMed] [Google Scholar]
  11. Reimann H. A., Coppola E. D., Villegas G. R. Serum complement defects in periodic diseases. Ann Intern Med. 1970 Nov;73(5):737–740. doi: 10.7326/0003-4819-73-5-737. [DOI] [PubMed] [Google Scholar]
  12. Richter C. P. BIOLOGICAL CLOCKS IN MEDICINE AND PSYCHIATRY: SHOCK-PHASE HYPOTHESIS. Proc Natl Acad Sci U S A. 1960 Nov;46(11):1506–1530. doi: 10.1073/pnas.46.11.1506. [DOI] [PMC free article] [PubMed] [Google Scholar]

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