Abstract
Among fifty-seven patients with proven coeliac disease three also had thyrotoxicosis, two insulin dependant diabetes, three fibrosing alveolitis and one each had vitiligo, rheumatoid arthritis and cryptogenic cirrhosis. Autoantibodies were demonstrated in twelve of thirty-one patients tested, seven of these twelve had one of the above associated conditions. Antireticulin antibodies were found in seven of twenty-three patients tested, and there was a significant association with dietary gluten. These findings appear to support that coeliac disease is associated with disturbed immunity and that a predisposition to autoimmunity may exist.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alp M. H., Wright R. Autoantibodies to reticulin in patients with idiopathic steatorrhoea, coeliac disease, and Crohn's disease, and their relation to immunoglobulins and dietary antibodies. Lancet. 1971 Sep 25;2(7726):682–685. doi: 10.1016/s0140-6736(71)92249-5. [DOI] [PubMed] [Google Scholar]
- Blecher T. E., Brzechwa-Ajdukiewicz A., McCarthy C. F., Read A. E. Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut. 1969 Jan;10(1):57–62. doi: 10.1136/gut.10.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CARPENTER C. C., SOLOMON N., SILVERBERG S. G., BLEDSOE T., NORTHCUTT R. C., KLINENBERG J. R., BENNETT I. L., Jr, HARVEY A. M. SCHMIDT'S SYNDROME (THYROID AND ADRENAL INSUFFICIENCY). A REVIEW OF THE LITERATURE AND A REPORT OF FIFTEEN NEW CASES INCLUDING TEN INSTANCES OF COEXISTENT DIABETES MELLITUS. Medicine (Baltimore) 1964 Mar;43:153–180. [PubMed] [Google Scholar]
- Doniach D., Walker J. G. A unified concept of autoimmune hepatitis. Lancet. 1969 Apr 19;1(7599):813–815. doi: 10.1016/s0140-6736(69)92072-8. [DOI] [PubMed] [Google Scholar]
- Douglas A. P., Crabbé P. A., Hobbs J. R. Immunochemical studies on the serum, intestinal secretions and intestinal mucosa in patients with adult celiac disease and other forms of the celiac syndrome. Gastroenterology. 1970 Sep;59(3):414–425. [PubMed] [Google Scholar]
- FULTHORPE A. J., ROITT I. M., DONIACH D., COUCHMAN K. A stable sheep cell preparation for detecing thyroglobulin auto-antibodies and its clinical applications. J Clin Pathol. 1961 Nov;14:654–660. doi: 10.1136/jcp.14.6.654. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fakhri O., Hobbs J. R. Detection of antibodies which can cooperate with lymphocytes. Lancet. 1972 Aug 26;2(7774):403–406. doi: 10.1016/s0140-6736(72)91799-0. [DOI] [PubMed] [Google Scholar]
- Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes. 1965 Oct;14(10):619–633. doi: 10.2337/diab.14.10.619. [DOI] [PubMed] [Google Scholar]
- Goudie R. B., Stuart-Smith D. A., Boyle I. T., Ferguson A. Serological diagnosis of idiopathic Addison's disease in patients on prolonged prednisolone therapy for steatorrhoea. Lancet. 1969 Jan 25;1(7587):186–188. doi: 10.1016/s0140-6736(69)91194-5. [DOI] [PubMed] [Google Scholar]
- Hellesen C., Friis T., Larsen E., Pock-Steen C. Small intestinal histology, radiology and absorption in hyperthyroidism. Scand J Gastroenterol. 1969;4(2):169–175. doi: 10.3109/00365526909179925. [DOI] [PubMed] [Google Scholar]
- Hobbs J. R. Immune imbalance in dysgammaglobulinaemia type IV. Lancet. 1968 Jan 20;1(7534):110–114. doi: 10.1016/s0140-6736(68)92721-9. [DOI] [PubMed] [Google Scholar]
- Hood J., Mason A. M. Diffuse pulmonary disease with transfer defect occurring with coeliac disease. Lancet. 1970 Feb 28;1(7644):445–447. doi: 10.1016/s0140-6736(70)90834-2. [DOI] [PubMed] [Google Scholar]
- Hooft C., Devos E., Kriekemans J., Van Damme J. Malabsorption and diabetes mellitus in children. Helv Paediatr Acta. 1968 Oct;23(5):478–488. [PubMed] [Google Scholar]
- Hooft C., Roels H., Devos E. Diabetes and coeliac disease. Lancet. 1969 Nov 29;2(7631):1192–1192. [PubMed] [Google Scholar]
- Irvine W. J., Clarke B. F., Scarth L., Cullen D. R., Duncan L. J. Thyroid and gastric autoimmunity in patients with diabetes mellitus. Lancet. 1970 Jul 25;2(7665):163–168. doi: 10.1016/s0140-6736(70)92531-6. [DOI] [PubMed] [Google Scholar]
- MACKAY I. R., RITCHIE B. DIFFUSE FIBROSING ALVEOLITIS (DIFFUSE INTERSTITIAL FIBROSIS OF THE LUNGS): TWO CASES WITH AUTOIMMUNE FEATURES. Thorax. 1965 May;20:200–205. doi: 10.1136/thx.20.3.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PITTMAN F. E., HOLUB D. A. SJOEGREN'S SYNDROME AND ADULT CELIAC DISEASE. Gastroenterology. 1965 Jun;48:869–876. [PubMed] [Google Scholar]
- Pagaltsos A. S., Kumar P. J., Willoughby J. M., Dawson A. M. In-vitro inhibition of leucocyte migration by sarcoid spleen suspension in coeliac disease and dermatitis herpetiformis. Lancet. 1971 Nov 27;2(7735):1179–1181. doi: 10.1016/s0140-6736(71)90491-0. [DOI] [PubMed] [Google Scholar]
- SALEM S. N., TRUELOVE S. C. SMALL-INTESTINAL AND GASTRIC ABNORMALITIES IN ULCERATIVE COLITIS. Br Med J. 1965 Mar 27;1(5438):827–831. doi: 10.1136/bmj.1.5438.827. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seah P. P., Fry L., Hoffbrand A. V., Holborow E. J. Tissue antibodies in dermatitis herpetiformis and adult coeliac disease. Lancet. 1971 Apr 24;1(7704):834–836. doi: 10.1016/s0140-6736(71)91499-1. [DOI] [PubMed] [Google Scholar]
- Siurala M., Varis K., Lamberg B. A. Intestinal absorption and autoimmunity in endocrine disorders. Acta Med Scand. 1968 Jul-Aug;184(1-2):53–64. doi: 10.1111/j.0954-6820.1968.tb02422.x. [DOI] [PubMed] [Google Scholar]
- Smith M. J., Benson M. K., Strickland I. D. Coeliac disease and diffuse interstitial lung disease. Lancet. 1971 Mar 6;1(7697):473–475. doi: 10.1016/s0140-6736(71)91089-0. [DOI] [PubMed] [Google Scholar]