Abstract
Four infants, two boys and two girls, with congenital nephrotic syndrome are reported in a single family. The disease process began during the first year of life. The disorder did not respond to corticosteroid therapy. One infant received cyclophosphamide therapy as well without avail. All four children died from intercurrent infection. The family tree is suggestive of an autosomal recessive inheritance.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ARNEIL G. C. 164 children with nephrosis. Lancet. 1961 Nov 18;2(7212):1103–1110. doi: 10.1016/s0140-6736(61)91026-1. [DOI] [PubMed] [Google Scholar]
- BARNETT H. L., FORMAN C. W., LAUSON H. D. The nephrotic syndrome in children. Adv Pediatr. 1952 Jan;5:53–128. [PubMed] [Google Scholar]
- Hoyer J. R., Michael A. F., Jr, Good R. A., Vernier R. L. The nephrotic syndrome of infancy: clinical, morphologic, and immunologic studies of four infants. Pediatrics. 1967 Aug;40(2):233–246. [PubMed] [Google Scholar]
- Kobayashi N. An immunohistochemical study on renal biopsies in children. Arch Dis Child. 1966 Oct;41(219):477–488. doi: 10.1136/adc.41.219.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LANGE K., WACHSTEIN M., WASSERMAN E., ALPTEKIN F., SLOBODY L. B. The congenital nephrotic syndrome. An immune reaction? Am J Dis Child. 1963 Apr;105:338–345. doi: 10.1001/archpedi.1963.02080040340003. [DOI] [PubMed] [Google Scholar]
- McDonald R., Wiggelinkhuizen J., Kaschula R. O. The nephrotic syndrome in very young infants. Am J Dis Child. 1971 Dec;122(6):507–512. doi: 10.1001/archpedi.1971.02110060077013. [DOI] [PubMed] [Google Scholar]
- NORIO R., HJELT L., HALLMAN N. CONGENITAL NEPHROTIC SYNDROME--AN INHERITED DISEASE?A PRELIMINARY REPORT. Ann Paediatr Fenn. 1964;10:223–227. [PubMed] [Google Scholar]
- PARKER R. A., PIEL C. F. The nephrotic syndrome in the first year of life. Pediatrics. 1960 Jun;25:967–976. [PubMed] [Google Scholar]
- VERNIER R. L., BRUNSON J., GOOD R. A. Studies on familial nephrosis. I. Clinical and pathologic study of four cases in a single family. AMA J Dis Child. 1957 May;93(5):469–485. [PubMed] [Google Scholar]