Abstract
This paper presents data on the absorption and disappearance of a new semisynthetic antibiotic—amoxycillin—in patients with pernicious anaemia and those with renal failure. Absorption of this drug is unimpaired in these patients. Adequate serum and urine levels are obtained even in patients with creatinine clearance levels below 10 ml/min. The half-life of this drug is markedly prolonged in patients undergoing regular dialysis therapy, and a single 250 mg dose will provide adequate serum levels for 24 hr, if this is given after dialysis is complete.
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Selected References
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- Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kunin C. M., Finkelberg Z. Oral cephalexin and ampicillin: antimicrobial activity, recovery in urine, and persistence in blood of uremic patients. Ann Intern Med. 1970 Mar;72(3):349–356. doi: 10.7326/0003-4819-72-3-349. [DOI] [PubMed] [Google Scholar]
- Sutherland R., Croydon E. A., Rolinson G. N. Amoxycillin: a new semi-synthetic penicillin. Br Med J. 1972 Jul 1;3(5817):13–16. doi: 10.1136/bmj.3.5817.13. [DOI] [PMC free article] [PubMed] [Google Scholar]