Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1975 Jan;51(591):15–17. doi: 10.1136/pgmj.51.591.15

Prostaglandin levels in blood plasma during asthmatic attacks in patients with aspirin idiosyncrasy

J C Delaney, J B Smith, M J Silver
PMCID: PMC2495671  PMID: 1161671

Abstract

It has been suggested that prostaglandin release is an important factor in the pathogenesis of bronchial asthma. Aspirin inhibits prostaglandin synthesis, yet there are a group of patients, with aspirin idiosyncrasy, who develop asthma after ingestion of aspirin. We measured prostaglandin levels in seven individuals with this syndrome. Only trace amounts of PGE2 and PGF2α were found in plasma during asthmatic attacks provoked by aspirin.

Full text

PDF
15

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anggård E. The isolation and determination of prostaglandins in lungs of sheep, guinea pig, monkey and man. Biochem Pharmacol. 1965 Nov;14(11):1507–1516. doi: 10.1016/0006-2952(65)90004-3. [DOI] [PubMed] [Google Scholar]
  2. Beguin F., Bygdeman M., Gréen K., Samuelsson B., Toppozada M., Wiqvist N. Analysis of prostaglandin F 2 and metabolites in blood during constant intravenous infusion of prostaglandin F 2 in the human female. Acta Physiol Scand. 1972 Nov;86(3):430–432. doi: 10.1111/j.1748-1716.1972.tb05349.x. [DOI] [PubMed] [Google Scholar]
  3. Caldwell B. V., Burstein S., Brock W. A., Speroff L. Radioimmunoassay of the F prostaglandins. J Clin Endocrinol Metab. 1971 Aug;33(2):171–175. doi: 10.1210/jcem-33-2-171. [DOI] [PubMed] [Google Scholar]
  4. Karim S. M., Sandler M., Williams E. D. Distribution of prostaglandins in human tissues. Br J Pharmacol Chemother. 1967;31:340–344. doi: 10.1111/j.1476-5381.1967.tb02003.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mathé A. A., Hedqvist P., Holmgren A., Svanborg N. Bronchial hyperreactivity to prostaglandin F 2 and histamine in patients with asthma. Br Med J. 1973 Jan 27;1(5847):193–196. doi: 10.1136/bmj.1.5847.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Piper P. J., Vane J. R. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature. 1969 Jul 5;223(5201):29–35. doi: 10.1038/223029a0. [DOI] [PubMed] [Google Scholar]
  7. Samter M., Beers R. F., Jr Concerning the nature of intolerance to aspirin. J Allergy. 1967 Nov;40(5):281–293. doi: 10.1016/0021-8707(67)90076-7. [DOI] [PubMed] [Google Scholar]
  8. Silver M. J., Smith J. B., Ingerman C., Kocsis J. J. Human blood prostaglandins: formation during clotting. Prostaglandins. 1972 Jun;1(6):429–436. doi: 10.1016/0090-6980(72)90011-1. [DOI] [PubMed] [Google Scholar]
  9. Smith A. P., Cuthbert M. F. Antagonistic Action of Aerosols of Prostaglandins F(2)alpha and E(2) on Bronchial Muscle Tone in Man. Br Med J. 1972 Jul 22;3(5820):212–213. doi: 10.1136/bmj.3.5820.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Smith A. P. Response of aspirin-allergic patients to challenge by some analgesics in common use. Br Med J. 1971 May 29;2(5760):494–496. doi: 10.1136/bmj.2.5760.494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Smith J. B., Willis A. L. Aspirin selectively inhibits prostaglandin production in human platelets. Nat New Biol. 1971 Jun 23;231(25):235–237. doi: 10.1038/newbio231235a0. [DOI] [PubMed] [Google Scholar]
  12. Unger W. G., Stamford I. F., Bennett A. Extraction of prostaglandins from human blood. Nature. 1971 Oct 1;233(5318):336–337. doi: 10.1038/233336b0. [DOI] [PubMed] [Google Scholar]
  13. Zusman R. M., Caldwell B. V., Speroff L., Behrman H. R. Radioimmunoassay of the A prostaglandins. Prostaglandins. 1972 Jul;2(1):41–53. doi: 10.1016/0090-6980(72)90028-7. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES