Abstract
Fifty-nine (42%) of 140 schizophrenic patients taking phenothiazines were found to have abnormal electrocardiograms. The abnormalities included T wave changes, S-T depression, P-R and Q-T prolongation, persistent sinus tachycardia (110 or more/min) and right bundle branch block.
In forty-eight (34%) of the fifty-nine patients, the ECG abnormalities disappeared after stopping the phenothiazine and reappeared on its resumption.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alexander C. S., Niño A. Cardiovascular complications in young patients taking psychotropic drugs. A preliminary report. Am Heart J. 1969 Dec;78(6):757–769. doi: 10.1016/0002-8703(69)90442-6. [DOI] [PubMed] [Google Scholar]
- Huston J. R., Bell G. E. The effect of thioridazine hydrochloride and chlorpromazine on the electrocardiogram. JAMA. 1966 Oct 3;198(1):134–138. doi: 10.1001/jama.198.1.134. [DOI] [PubMed] [Google Scholar]
- KELLY H. G., FAY J. E., LAVERTY S. G. THIORIDAZINE HYDROCHLORIDE (MELLARIL): ITS EFFECT ON THE ELECTROCARDIOGRAM AND A REPORT OF TWO FATALITIES WITH ELECTROCARDIOGRAPHIC ABNORMALITIES. Can Med Assoc J. 1963 Sep 14;89:546–554. [PMC free article] [PubMed] [Google Scholar]
- Richardson H. L., Graupner K. I., Richardson M. E. Intramyocardial lesions in patients dying suddenly and unexpectedly. JAMA. 1966 Jan 24;195(4):254–260. [PubMed] [Google Scholar]
- Wendkos M. H. Cardiac changes related to phenothiazine therapy, with special reference to thioridazine. J Am Geriatr Soc. 1967 Jan;15(1):20–28. doi: 10.1111/j.1532-5415.1967.tb05330.x. [DOI] [PubMed] [Google Scholar]
