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. 1990 Jul;64(7):3376–3381. doi: 10.1128/jvi.64.7.3376-3381.1990

Abrogation of Fv-1 restriction by genome-deficient virions produced by a retrovirus packaging cell line.

L R Boone 1, C L Innes 1, C K Heitman 1
PMCID: PMC249585  PMID: 1693703

Abstract

The Fv-1b-mediated restriction of N-tropic retrovirus vector infection of BALB/3T3 cells was partially abrogated by prior infection with N-tropic murine leukemia virus. Likewise, abrogation of the Fv-1b restriction of N-tropic murine leukemia virus replication was accomplished by prior infection with genome-deficient virions produced by an N-tropic murine leukemia virus packaging cell line. The latter observation suggests that the Fv-1 target in genome-deficient virions abrogates Fv-1 restriction in the absence of any viral genome-directed processes.

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Selected References

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